Dear David You are a special brave person and i wish you all the best and great success on your dual fight. You are the only person i have heard of that is on both Ibrutinib and Imatinib at the same time My best regards Giora
נשלח מה-iPhone שלי ב-3 באפר׳ 2015, בשעה 16:51, David Bradley <[email protected]> כתב/ה: > Thanks Beth! > > Time for another update. Based on my PCR that was negative for CML in > December, and my looming CLL, I was taken off Gleevec, and started Imbruvica > for my CLL, with the hope that the CML would remain dormant. There have been > two slip-ups since then. The Imbruvica triggered a heart problem, an atrial > fibrillation in February. At the end of a week in hos[pital, I was given one > of those treatments with the electric paddles and fortunately immediately > went back into a good rhythm. Arriving home, I started a recovery process in > which I am still weaker than I was, but a bit better every day. > > Then it was time for a new PCR. My old nemesis, the Philadelphia chromosome, > was back (that was quick!). So now I am back on Gleevec. My Imbruvica has > to be on a 1/3 basis, since both drugs are Bruton's Tyrosine Kinase > inhibitors, and both use the CYP3A4 pathway. > > It has only been since December that I was off Gleevec, but my heartburn > reminds me of the main downside I had from it. Still, I have faith it can > keep the CML at bay. > > Anyway, as I said, I'm better every day, and besides, spring has finally come > to northern Michigan. > > David > > > >> On Wednesday, December 17, 2014 at 12:35:08 PM UTC-5, Beth wrote: >> Good luck to you David. It sounds so hard..glad you reconnected >> here....after being diagnosed and doing well for 12 years....hope the meds >> support you well with the CLL. happiest of holidays to you and yours. Beth. >> >> >> >> -----Original Message----- >> From: Richard H <[email protected]> >> To: cmlhope <[email protected]> >> Cc: icandoallttc <[email protected]> >> Sent: Sun, Dec 14, 2014 12:33 am >> Subject: Re: [CMLHope] Dual Diagnosis: CLL/ CML >> >> I could not meet the requirements. I have too many other health issues that >> would interfere with the results they were looking for. When I was first >> diagnosed they ruled me out of a BMT for the same reasons. >> >> Richard H. >> >>> On Saturday, December 13, 2014 2:07:12 PM UTC-6, Icandoallttc wrote: >>> Hi David >>> So good to hear from you. >>> Marty sent us a site not long ago about a study for going off Gleevec. >>> There are certain things you must meet to be in the study. >>> Glad you are negative. >>> Blessings >>> Jeanie >>> >>> Sent from my iPhone >>> >>> On Dec 13, 2014, at 12:00 PM, [email protected] wrote: >>> >>>> Hi, >>>> >>>> Hello everyone. >>>> >>>> I have posted here long ago, when I was first diagnosed with CML, in 2003. >>>> At the time, I started on Gleevec, and immediately had a Complete >>>> Remission, via FISH. Unfortunately, I also showed signs of CLL, which was >>>> confirmed. The CLL has been on "watchful waiting" until now. >>>> >>>> Recently my counts got very negative, due to the CLL, and I went to Mayo >>>> and found I have a 17p deletion, which is quite negative. For the CLL, I >>>> will go on Ibrutinib, a targeted therapy. Since Ibrutinib is a tyrosine >>>> kinase inhibitor, I will need to stop Gleevec, at least for a while. >>>> >>>> I kind of wish my onc had been doing PCR's for a while, but at Mayo they >>>> did one and found my CML was undetectable. >>>> >>>> Can anyone point me to any studies about stopping Gleevec after long >>>> periods (in my case around 10 years) of Complete (or molecular) remission? >>>> >>>> The current plan is to check with regular PCR's for a reemergence of the >>>> BCR-ABL. >>>> >>>> Best wishes to all... >>>> >>>> David >>>> >>>> >>>> -- >>>> -- >>>> [CMLHope] >>>> A support group of http://cmlhope.com >>>> ------------------------------------------------- >>>> >>>> You received this message because you are subscribed to the Google Groups >>>> "CMLHope" group. >>>> To post to this group, send email to [email protected] >>>> To unsubscribe from this group, send email to [email protected] >>>> For more options, visit this group at >>>> http://groups.google.com/group/CMLHope >>>> --- >>>> You received this message because you are subscribed to the Google Groups >>>> "CMLHope" group. >>>> To unsubscribe from this group and stop receiving emails from it, send an >>>> email to [email protected]. >>>> For more options, visit https://groups.google.com/d/optout. >> >> -- >> -- >> [CMLHope] >> A support group of http://cmlhope.com >> ------------------------------------------------- >> >> You received this message because you are subscribed to the Google Groups >> "CMLHope" group. >> To post to this group, send email to [email protected] >> To unsubscribe from this group, send email to [email protected] >> For more options, visit this group at http://groups.google.com/group/CMLHope >> --- >> You received this message because you are subscribed to the Google Groups >> "CMLHope" group. >> To unsubscribe from this group and stop receiving emails from it, send an >> email to [email protected]. >> For more options, visit https://groups.google.com/d/optout. > > -- > -- > [CMLHope] > A support group of http://cmlhope.com > ------------------------------------------------- > > You received this message because you are subscribed to the Google Groups > "CMLHope" group. > To post to this group, send email to [email protected] > To unsubscribe from this group, send email to > [email protected] > For more options, visit this group at http://groups.google.com/group/CMLHope > --- > You received this message because you are subscribed to the Google Groups > "CMLHope" group. > To unsubscribe from this group and stop receiving emails from it, send an > email to [email protected]. > For more options, visit https://groups.google.com/d/optout. -- -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [email protected] For more options, visit this group at http://groups.google.com/group/CMLHope --- You received this message because you are subscribed to the Google Groups "CMLHope" group. To unsubscribe from this group and stop receiving emails from it, send an email to [email protected]. For more options, visit https://groups.google.com/d/optout.
