Hi Choi Yes I developed mutants for gleevec tasigna and sprycel. I was recently put on ponatinib and it is supposed to be mutant resistant. He could talk to his onc about it. I am doing pretty good so far.
Prayers & Blessings Jeanie 🐟🐟18,s Dx 1/2004 Started Gleevec 2/2004 Started Tasigna 9/2009 Started Sprycel 11/2009 Started Ponatinib January 2015 > On Jun 9, 2015, at 6:47 AM, Choi <[email protected]> wrote: > > Hi, this is Choi from South Korea. One of my CML friends had some problems > and I just wonder who had a similar experience. > > He was diagnosed with CML chronic phase on july 2012 and started Gleevec > 400mg for 16 months and switched to Sprycel due to E355G mutation. > At that time his PCR was 1.89. He started Sprycel and E355G mutaiton was > disappered. He was on Sprycel for 12 months. > He developed pleural effusions after 12 months of Sprycel at that time his > dose was 100mg. His doctor stopped Sprycel for 2 weeks and restarted Sprycel > 80mg for 3 months. > Once again he developed pleural effusions so he was off Sprycel for 4 weeks > and restarted Sprycel 60mg until now and still had minor pleural effusions. > PCR count was 0.37, 0.47, 0.45 and never drop to under 0.1% so his doctor was > considering to switch to other drugs but hesitated to switch because of he > had E355G mutation. > Is there any one who had a similar experience? > > Choi. > -- > -- > [CMLHope] > A support group of http://cmlhope.com > ------------------------------------------------- > > You received this message because you are subscribed to the Google Groups > "CMLHope" group. > To post to this group, send email to [email protected] > To unsubscribe from this group, send email to > [email protected] > For more options, visit this group at http://groups.google.com/group/CMLHope > --- > You received this message because you are subscribed to the Google Groups > "CMLHope" group. > To unsubscribe from this group and stop receiving emails from it, send an > email to [email protected]. > For more options, visit https://groups.google.com/d/optout. -- -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [email protected] For more options, visit this group at http://groups.google.com/group/CMLHope --- You received this message because you are subscribed to the Google Groups "CMLHope" group. To unsubscribe from this group and stop receiving emails from it, send an email to [email protected]. For more options, visit https://groups.google.com/d/optout.
