On Tuesday, June 9, 2015, Choi <saehyun...@naver.com> wrote:

> Hi, this is Choi from South Korea. One of my CML friends had some problems
> and I just wonder who had a similar experience.
>
> He was diagnosed with CML chronic phase on july 2012 and started Gleevec
> 400mg for 16 months and switched to Sprycel due to E355G mutation.
> At that time his PCR was 1.89. He started Sprycel  and E355G mutaiton was
> disappered. He was on Sprycel for 12 months.
> He developed pleural effusions after 12 months of Sprycel at that time his
> dose was 100mg. His doctor stopped Sprycel for 2 weeks and restarted
> Sprycel 80mg for 3 months.
> Once again he developed pleural effusions so he was off Sprycel for 4
> weeks and restarted Sprycel 60mg until now and still had minor pleural
> effusions.
> PCR count was 0.37, 0.47, 0.45 and never drop to under 0.1% so his doctor
> was considering to switch to other drugs but hesitated to switch because of
> he had E355G mutation.
> Is there any one who had a similar experience?
>
> Choi.
>
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