Lovely Beth! 18's,
Marty On Sun, Jan 28, 2018 at 11:47 PM, bkbarney via CMLHope < [email protected]> wrote: > HI Choi, > > This sounds very difficult. While your friend is not in molecular > remission his blood work is stable..it has not spiked while on less > sprycel. Is it possible he could go on 40 mgs or 40 five days a week and 60 > two days a week? Sometimes just enough medication will keep the plural > effusions at bay, while still keeping the cancer at bay as well. The risk > is getting resistant, which he has already done with the Gleevec. But there > are other options and another in trials that works in a different area than > the other TKI's that is showing promise. So hopefully your friend can find > the right med at the right dose to keep his disease in check. He may not > tolerate full doses of the more recent and more potent meds..but there are > several left to try. > I can only tolerate 40 a day. Keeps me in check. I cannot go off med as I > cannot take a high enough dose to get into that level of remission..but it > works for me. > > Others who did not tolerate Sprycel have gone on bosutinib and it has > worked for them... > > Take good care.. > > 18's hope and love, > > > Beth > > > -----Original Message----- > From: Jamie Tufariello <[email protected]> > To: cmlhope <[email protected]> > Sent: Thu, Jan 25, 2018 10:44 am > Subject: Re: [CMLHope] off Sprycel > > > > On Tuesday, June 9, 2015, Choi <[email protected]> wrote: > > Hi, this is Choi from South Korea. One of my CML friends had some problems > and I just wonder who had a similar experience. > > He was diagnosed with CML chronic phase on july 2012 and started Gleevec > 400mg for 16 months and switched to Sprycel due to E355G mutation. > At that time his PCR was 1.89. He started Sprycel and E355G mutaiton was > disappered. He was on Sprycel for 12 months. > He developed pleural effusions after 12 months of Sprycel at that time his > dose was 100mg. His doctor stopped Sprycel for 2 weeks and restarted > Sprycel 80mg for 3 months. > Once again he developed pleural effusions so he was off Sprycel for 4 > weeks and restarted Sprycel 60mg until now and still had minor pleural > effusions. > PCR count was 0.37, 0.47, 0.45 and never drop to under 0.1% so his doctor > was considering to switch to other drugs but hesitated to switch because of > he had E355G mutation. > Is there any one who had a similar experience? > > Choi. > -- > -- > [CMLHope] > A support group of http://cmlhope.com > ------------------------------------------------- > > You received this message because you are subscribed to the Google Groups > "CMLHope" group. > To post to this group, send email to [email protected] > To unsubscribe from this group, send email to > [email protected] > For more options, visit this group at http://groups.google.com/group > /CMLHope > --- > You received this message because you are subscribed to the Google Groups > "CMLHope" group. > To unsubscribe from this group and stop receiving emails from it, send an > email to [email protected]. > For more options, visit https://groups.google.com/d/optout. > > -- > -- > [CMLHope] > A support group of http://cmlhope.com > ------------------------------------------------- > > You received this message because you are subscribed to the Google Groups > "CMLHope" group. > To post to this group, send email to [email protected] > To unsubscribe from this group, send email to CMLHope-unsubscribe@ > googlegroups.com > For more options, visit this group at http://groups.google.com/ > group/CMLHope > --- > You received this message because you are subscribed to the Google Groups > "CMLHope" group. > To unsubscribe from this group and stop receiving emails from it, send an > email to [email protected]. > For more options, visit https://groups.google.com/d/optout. > > -- > -- > [CMLHope] > A support group of http://cmlhope.com > ------------------------------------------------- > > You received this message because you are subscribed to the Google Groups > "CMLHope" group. > To post to this group, send email to [email protected] > To unsubscribe from this group, send email to CMLHope-unsubscribe@ > googlegroups.com > For more options, visit this group at http://groups.google.com/ > group/CMLHope > --- > You received this message because you are subscribed to the Google Groups > "CMLHope" group. > To unsubscribe from this group and stop receiving emails from it, send an > email to [email protected]. > For more options, visit https://groups.google.com/d/optout. > -- -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [email protected] For more options, visit this group at http://groups.google.com/group/CMLHope --- You received this message because you are subscribed to the Google Groups "CMLHope" group. To unsubscribe from this group and stop receiving emails from it, send an email to [email protected]. For more options, visit https://groups.google.com/d/optout.
