John,
When you were on sprycel did you get to PCRU? My husband was on sprycel for 3
years and then, just as you, had to go off because of pleural effusion. He was
undetectable for 2 years and lost his PCRU in 2 months. He is now on
bosulif.....first 100 mg which was not working.....then on 200 mg which he will
find out in July if it is doing anything good.
I am not familiar with omacetaxine. Can you enlighten us on what it is and
what it is for?
Wish you well on ponatinib.
Joyce in IL
On Jun 9, 2015, at 6:31 AM, John Barrons wrote:
> Hi Choi I was on sprycel and to go off it because of pleural effusion. I then
> went on omacetaxine for a couple of years and finally am on ponatinib. I only
> take normally one pill a week it is a strong drug so I am off it for three
> weeks. John B
>
>
>
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>
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> Sent from my iPad
>
> On Jun 9, 2015, at 6:47 AM, Choi <[email protected]> wrote:
>
>> Hi, this is Choi from South Korea. One of my CML friends had some problems
>> and I just wonder who had a similar experience.
>>
>> He was diagnosed with CML chronic phase on july 2012 and started Gleevec
>> 400mg for 16 months and switched to Sprycel due to E355G mutation.
>> At that time his PCR was 1.89. He started Sprycel and E355G mutaiton was
>> disappered. He was on Sprycel for 12 months.
>> He developed pleural effusions after 12 months of Sprycel at that time his
>> dose was 100mg. His doctor stopped Sprycel for 2 weeks and restarted Sprycel
>> 80mg for 3 months.
>> Once again he developed pleural effusions so he was off Sprycel for 4 weeks
>> and restarted Sprycel 60mg until now and still had minor pleural effusions.
>> PCR count was 0.37, 0.47, 0.45 and never drop to under 0.1% so his doctor
>> was considering to switch to other drugs but hesitated to switch because of
>> he had E355G mutation.
>> Is there any one who had a similar experience?
>>
>> Choi.
>>
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