OK, I found the MS Knowledge Base article on how to deal with your problem.
Not exactly a walk in the park:

http://support.microsoft.com/kb/923100

On Mon, Dec 21, 2009 at 12:04 PM, John Emmerling <[email protected]>wrote:

> a.) A quick visit to Google tells me you have a difficult problem if you
> are getting this error message 0X643.  A quick overview suggests you will
> need some technical savvy to get your way through it.  If practical, you
> might want to try reinstalling Windows at this point.  The way I avoid this
> type of problem is to just allow Windows Update to perform whatever update
> it wants to, whenever it wants to.  Maybe Geeks on Call (or someone else on
> this list) can help.  On the other hand, if you are not experiencing other
> symptoms than this Windows Update error, then you could just ignore it for
> the time being.
> b.) I don't know how to tell whether any given program requires .NET.  I
> determined (again via Google) that Office 2007 requires .NET v1.1.  It is
> mostly a programmer's concern.  For a long time, the programming tool of
> choice for Windows was Visual Basic.  I suspect a lot of software being sold
> is still written in that, which will run just fine.  The .NET equivalent of
> this is VB.NET, plus a brand new language known as C# was introduced at
> the same time, which grew rapidly in popularity.  But if you're not a
> programmer, you could care less.  Unfortunately, both "traditional" Visual
> Basic and "new fangled" VB.NET and C# compilers create files with either
> the extension ".exe" or ".dll".  I don't know how to tell from looking at
> these how the programs were written.
>
> A lot of software running on Windows is cross-platform, in which case it
> may have been written in C++ and compiled on Windows using Visual C++.
> There is also some stuff written in Java (I am a Java programmer).  The Java
> programs are easiest to identify, but tend to be used by people having
> specialized interests.
>
> Hope this helps somewhat!
>
> --John Emmerling


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