On Jan 17, 2014, at 1:54 PM, John Clark <[email protected]> wrote:
On Fri, Jan 17, 2014 at 12:23 PM, Edgar L. Owen <[email protected]>
wrote:
> There are thousands of chemicals that are good organic solvents
that aren't anesthetics. I don't think that has anything to do with
it...
Why do you think some people like to inhale cleaning products or
airplane glue which is full of industrial solvents? It might destroy
their liver but it will get them high before they die. Anyway do a
web search for "Meyer Overton" or "Meyer Overton Rule", you'll find
tons of stuff; 115 years old and still going strong. I'd like to
know why.
I think that one possible explaination is that neurochemistry is a
very fragile thing. And solvents, being reactive, can easily throw a
wrench into the whole thing. Even non-reactive chemicals, like Xenon
have been found to make a nearly ideal anastheitc.
Inserting new chemicals, which we haven't evolved to handle, into the
brain are almost sure to disrupt things. If the chemical can be
cleared away without lasting harm then it can make a useful anesthetic.
Jason
John K Clark
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