On Fri, Jul 31, 2020 at 7:37 PM PGC <[email protected]> wrote:

>
>
> On Saturday, August 1, 2020 at 2:26:40 AM UTC+2, Jason wrote:
>>
>>
>>
>> On Fri, Jul 31, 2020 at 7:20 PM PGC <[email protected]> wrote:
>>
>>>
>>>
>>> On Saturday, August 1, 2020 at 1:12:49 AM UTC+2, Jason wrote:
>>>>
>>>> There have been 65 studies on HCQ. Of all the tests that looked at
>>>> giving it early in the disease, or prophylactically, they showed HCQ was
>>>> beneficial. This site summarizes them all: https://c19study.com/
>>>>
>>>> The only studies that have shown HCQ to be ineffective are those where
>>>> it is given late in the disease progression (when the disease shifts from
>>>> the viral replication phase to an immune system dysregulation phase
>>>> <https://www.evms.edu/media/evms_public/departments/internal_medicine/EVMS_Critical_Care_COVID-19_Protocol.pdf>
>>>> (see page 2)). Even then, 61% of studies have shown some effectiveness even
>>>> when it is given late.
>>>>
>>>> Given the well-established safety
>>>> <https://www.cdc.gov/malaria/resources/pdf/fsp/drugs/Hydroxychloroquine.pdf>
>>>> record of HCQ, this is the dilemma we face:
>>>>
>>>> HCQ works HCQ doesn't work
>>>> HCQ widely dispensed 10,000s of thousands of lives saved $20 wasted
>>>> per patient
>>>> HCQ use restricted 10,000s of thousands of needless deaths $0 wasted
>>>> per patient
>>>>
>>>> Even in the face of impartial information on its effectiveness, the
>>>> decision is clear.
>>>>
>>>
>>>
>>> https://www.who.int/news-room/detail/04-07-2020-who-discontinues-hydroxychloroquine-and-lopinavir-ritonavir-treatment-arms-for-covid-19
>>>
>>> Why not find out from the WHO or the steering committee itself? Just be
>>> prepared to wait as I believe they are somewhat busy.
>>>
>>> But contact them
>>>
>>
>> Find out what from the WHO?
>>
>
> Why they discontinued the treatment arm and why you think they should
> re-establish it (again btw) to save thousands of lives, with your table and
> the website. PGC
>
>>
>
It's purely a decision theory problem. They WHO is not infallible (and have
demonstrated that recently), the science on HCQs effectiveness is mixed,
the science on its safety is clear.

Given that there is a clearly optimal decision with a higher expected value.

The very link you provided says they only cancelled only the late stage
testing. They are continuing early and prophylactic use tests.

"This decision applies only to the conduct of the Solidarity trial in
hospitalized patients and does not affect the possible evaluation in other
studies of hydroxychloroquine or lopinavir/ritonavir in non-hospitalized
patients or as pre- or post-exposure prophylaxis for COVID-19."


Jason

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