On 7/31/2020 5:49 PM, Jason Resch wrote:
On Fri, Jul 31, 2020 at 7:37 PM PGC <[email protected]
<mailto:[email protected]>> wrote:
On Saturday, August 1, 2020 at 2:26:40 AM UTC+2, Jason wrote:
On Fri, Jul 31, 2020 at 7:20 PM PGC <[email protected]> wrote:
On Saturday, August 1, 2020 at 1:12:49 AM UTC+2, Jason wrote:
There have been 65 studies on HCQ. Of all the tests
that looked at giving it early in the disease, or
prophylactically, they showed HCQ was beneficial. This
site summarizes them all: https://c19study.com/
The only studies that have shown HCQ to be ineffective
are those where it is given late in the disease
progression (when the disease shifts from the viral
replication phase to an immune system dysregulation
phase
<https://www.evms.edu/media/evms_public/departments/internal_medicine/EVMS_Critical_Care_COVID-19_Protocol.pdf>
(see page 2)). Even then, 61% of studies have shown
some effectiveness even when it is given late.
Given the well-established safety
<https://www.cdc.gov/malaria/resources/pdf/fsp/drugs/Hydroxychloroquine.pdf>
record of HCQ, this is the dilemma we face:
HCQ works HCQ doesn't work
HCQ widely dispensed 10,000s of thousands of lives
saved $20 wasted per patient
HCQ use restricted 10,000s of thousands of needless
deaths $0 wasted per patient
Even in the face of impartial information on its
effectiveness, the decision is clear.
https://www.who.int/news-room/detail/04-07-2020-who-discontinues-hydroxychloroquine-and-lopinavir-ritonavir-treatment-arms-for-covid-19
Why not find out from the WHO or the steering committee
itself? Just be prepared to wait as I believe they are
somewhat busy.
But contact them
Find out what from the WHO?
Why they discontinued the treatment arm and why you think they
should re-establish it (again btw) to save thousands of lives,
with your table and the website. PGC
It's purely a decision theory problem. They WHO is not infallible (and
have demonstrated that recently), the science on HCQs effectiveness is
mixed, the science on its safety is clear.
Given that there is a clearly optimal decision with a higher expected
value.
No, there is not. The trials show some improvement for ill persons. It
doesn't show there would be no harm in using it as a preventative in
well persons.
Brent
The very link you provided says they only cancelled only the late
stage testing. They are continuing early and prophylactic use tests.
"This decision applies only to the conduct of the Solidarity trial
in hospitalized patients and does not affect the possible
evaluation in other studies of hydroxychloroquine or
lopinavir/ritonavir in non-hospitalized patients or as pre- or
post-exposure prophylaxis for COVID-19."
Jason
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