Dear Dr. Isiegas,

I will add my support to the extended concept of information that inheres in the work of Robert Ulanowicz and John Collier. I would just add that I like to call it information-as-process, to call attention to its 'structure' being dynamic, with individual neurones involved in a cyclic (better spiral or sinusoidal) movement between states of activation and inhibition. I have ascribed an extension of logic to this form of alternating actual and potential states in complex processes at all levels of reality.

Best wishes,

Joseph B.

----- Original Message ----- From: "Robert E. Ulanowicz" <>
To: "Carolina Isiegas" <>
Cc: <>
Sent: Wednesday, December 03, 2014 6:30 PM
Subject: Re: [Fis] Neuroinformation?

Dear Dr. Isiegas:

I envision neuroinformation as the mutual information of the neuronal
network where synaptic connections are weighted by the frequencies of
discharge between all pairs of neurons. This is directly analogous to a
network of trophic exchanges among an ecosystem, as illustrated in

Please note that this measure is different from the conventional
sender-channel-receiver format of communications theory. It resembles more
the "structural information" inhering in the neuronal network. John
Collier (also a FISer) calls such information "enformation" to draw
attention to its different nature.

With best wishes for success,

Bob Ulanowicz

Dear list,

    I have been reading during the last year all these interesting
exchanges. Some of them terrific discussions! Given my scientific
(Molecular Neuroscience), I would like to hear your point of view on the
topic of neuroinformation, how information "exists" within the Central
Nervous Systems. My task was experimental; I was interested in
investigating the molecular mechanisms underlying learning and memory,
specifically, the role of the cAMP-PKA-CREB signaling pathway in such
functions (In Ted Abel´s Lab at the University of Pennsylvania, where I
spent 7 years). I generated several genetically modified mice in which I
could regulate the expression of this pathway in specific brain regions
in which I studied the effects of upregulation or downregulation at the
synaptic and behavioral levels. However, I am conscious that the
"information flow" within the mouse Nervous System is far more complex
in the "simple" pathway that I was, my concrete question for
you "Fishers" or "Fisers", how should we contemplate the micro and macro
structures of information within the neural realm? what is

Best wishes,

Carolina Isiegas
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