I'm using a laptop with Vista, Office 2007 and JAWS 9
I also use a desktop with XP, Office 2007 and JAWS 9

On the laptop I have noticed an occasional problem with the Alt F4
combination not working.  It's a little irritating, but There are other
ways around it that are quite quick.  Shutting down the computer can be
done with the Windows Key to open the main menu, then pressing U to get
to the shut down menu.

Vista and Office 2007 have some significant changes, and if you are new
to them they can be rather frustrating.
Remember that many of the key strokes you  used in previous versions of
Office still work in 2007.
Alt O and then F brings you to the Font menu.
Alt T and then S opens the spell checker.

I stayed with XP on my desk top because of familiarity, but i have come
to really like Office 2007.
I recommend that those who are new to Office 2007 take some time, when
they don't have to get something done and explore.
The menus are different, and you just have to learn a few new ways of
getting to things.
Alt P brings you to the Page menu and then you can tab through the
various options there.
As you do, take note of the actions you use, and record them on a
separate cheat sheet that you can go back to quickly for reference. 
Eventually you will learn the key strokes and you won't need the cheat
sheet as much.
The menu's on the top of the screen have different names.  But if you go
to the Page menu, for example, you can arrow across to the other menus,
learn their names and tab through the options under them  
The Home menu, for example, contains the old Edit menu items.  There is a
Mailing Tab where you will find the envelope and label options, instead
of under the old Tool menu.
I think Office 2007 is doable for us since Microsoft has made virtually
everything accessible for us.
Blessings, 
Tom
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