We've known for a long time that our antibody-forming system adapts
itself to every microbe we encounter.  What we didn't understand fully
is exactly how this happens. Now that we know, we can begin to find
ways to manipulate this process so illnesses can be prevented or made
significantly less dangerous.

When the body encounters a foreign invader, like a virus or bacterium,
it immediately begins to find a way to neutralize it by means of
cellular or antibody-mediated defenses. Part of the process involves
tailoring the genes that code for antibodies to specific viruses or
bacteria. Researchers have known that this involves two types of
genetic manipulation. One type changes a single gene at a time, and
the other type changes multiple genes at the same time.  Multiple
genes can be modified simultaneously to make the "evolutionary leap"
necessary to stave off infection. You treat DNA responsible for making
antibody molecules with an enzyme, called activation-induced
deaminase, while the DNA copies RNA polymerase. Like a scanner, RNA
polymerase moves across the DNA to copy it. When this scanning process
moves smoothly, there were either single mutations or no mutations.
We can now stall the RNA polymerase (under certain conditions) as it
"scans",  causing cluster mutations in the DNA, adapting our
antibodies for a rapid and effective response to a new microbial
invader.  Germs are mutating all over the place - we can now "plan"
mutations of our own to save us as global warming makes infectious
diseases one the biggest threats to human survival.  Personally, I
would rather leap into a new form of existence much more sensible than
the human one,  No work seems to being done on this.


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