In my opinion, you want a transistor rated at the full anode-voltage in 
order to ensure reliability. This is probably more critical for MOS 
devices, because of the risk of oxide breakdown.

Basically, when the cathode driver is off, there is only leakage current, 
typically less than 1uA. Therefore, the voltage-drop across the anode 
resistor is about zero. If you consider the nixie to be a resistive device, 
it's voltage-drop will be about zero. Therefore, almost the entire anode 
voltage will appear across the driver. 

For bipolar devices, you might be able to use a Vceo rating less than the 
anode supply-voltage because breakdown isn't destructive as long as the 
current is limited. I suspect that NPN drivers with Vceo less than the 
anode voltage actually begin to breakdown, and as the current increases the 
voltage-drop across the tube & anode resistor will increase; this causes 
the voltage across the NPN to drop. At some point, equilibrium is reached. 
What matters the most is if the leakage current at equilibrium is enough to 
cause visible glowing. Leakage is exponentially temperature-dependent.

I thought about measuring the voltage-drop across an un-ionized nixie with 
a voltmeter, but my DMM's impedance is only 10Meg so I doubt I would get an 
accurate reading. 


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