I've used the ISD chips quite a bit, including building them into products, 
and I've generally had very good experiences with them.  They've gotten 
considerably cheaper over the years, and they're available in more 
high-volume packages than they used to be, but they're still fundamentally 
the same chip.

Sure, if I wanted to have a long recording time, or DC-quality audio, I'd 
go for a flash-based digital solution.  But for things like clock chimes in 
Nixie clocks (short duration, limited frequency response that actually can 
make the chime sound better, and very limited production quantities), 
they're a really good fit.  There's essentially no programming needed to 
use them, and although I now have a semi-permanent breadboard jig to load 
the audio, for a long time I just used a few clip leads.  So far, I've 
noticed no sound degradation even in devices that are nearly 20 years old, 
which tends to support their claimed 100-year retention time.
~~
Mark Moulding

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