----- Original Message ----- From: "Marshall Dudley" <[email protected]>
> [email protected] wrote: > > Marshall: I can only quote Ivan with regard to the mechanism of silver > > > absorption into the body. My background is NOT in physiology or related > > fields so I can't comment further. If others, versed in the appropriate > > fields would like to contribute their thoughts, please do. Roger > > I have read, and challenged, his postings several times. I don't beleive he has > ever provided any experimental evidence, or cites for his opinion. I have asked to be informed of any reason to not believe what I have written is true, you were not among the one (hello Roger) that did so. Here is one reference I posted a month or so ago http://www.chiro.org/places/minerals.shtml and you might like to read part of a message (below) I sent in July... you must have missed it. I didn't come to this position lightly...it was only after 6 mths of biochem and biology lectures that my suspicion firmed...and it seems to me that we may as well hold the correct method of silver absorption because it is fundamental to understanding the anticeptic action and fate of silver in the body. If you can refute this mechanism please do so, its no problem to me, I just want to be able to make judgements about silver generating doses and so on from a factual base. (see below) > I disagree with them. Once I do some tests I hope to get done in the next day or > so, I should have evidence to support my stand, or will change my stand to his. > > Marshall Here is a representative abstract regarding mineral absorption : "The regulation of mineral absorption in the gastrointestinal tract. Proc Nutr Soc 1999 Feb;58(1):147-53 (ISSN: 0029-6651) Powell JJ; Jugdaohsingh R; Thompson RP [Find other articles with these Authors] Gastrointestinal Laboratory, Rayne Institute, St Thomas' Hospital, London, UK. [email protected]. The absorption of metal ions in the mammalian single-stomached gut is fortunately highly selective, and both luminal and tissue regulation occur. Initially, assimilation of metal ions in an available form is facilitated by the intestinal secretions, chiefly soluble mucus (mucin) that retards hydrolysis of ions such as Cu, Fe and Zn. Metal ions then bind and traverse the mucosally-adherent mucus layer with an efficiency M+ > M2+ > M3+. At the mucosa Fe3+ is probably uniquely reduced to Fe2+, and all divalent cations (including Fe2+) are transported by a membrane protein (such as divalent cation transporter 1) into the cell. This minimizes absorption of toxic trivalent metals (e.g. Al3+). Intracellular metal-binding molecules (such as mobilferrin) may be present at the intracellular side of the apical membrane, anchored to a transmembrane protein such as an integrin complex. This mobilferrin would receive the metal ion from divalent cation transporter 1 and, with part of the integrin molecule, transport the metal to the cytosol for safe sequestration in a larger complex such as ferritin or 'paraferritin'. beta 2-Microglobulin and HFE (previously termed human leucocyte antigen H) may be involved in stabilizing metal mobilferrin-integrin to form this latter complex. Finally, a systemic metal-binding protein such as transferrin may enter the antiluminal (basolateral) side of the cell for binding of the sequestered metal ion and delivery to the circulation. Regulatory proteins, such as HFE, may determine the degree of ion transport from intestinal cells to the circulation. Gradients in pH and perhaps pCa or even pNa could allow the switching of ions between the different transporters throughout this mechanism. " Regards Ivan. -- The silver-list is a moderated forum for discussion of colloidal silver. To join or quit silver-list or silver-digest send an e-mail message to: [email protected] -or- [email protected] with the word subscribe or unsubscribe in the SUBJECT line. To post, address your message to: [email protected] Silver-list archive: http://escribe.com/health/thesilverlist/index.html List maintainer: Mike Devour <[email protected]>
