CCreel wrote:
< I think you know I have a great deal of respect for your work. I've
mentioned this more than once on another list to which we both belong. But
I think if you are to make a suggestion like NO and insist it CAN be
done,
the onus of responsibility is on you to explain......
The Universe supports these people as best as it can. But sometimes there are
hard, cold facts we wish weren't there that require some thinking outside of
the box to get around them. >
Catherine, I thank you again for your appreciation of my little
contribution. I dedicate
this expression of respect to my teachers who taught me the basics and to the
pioneers
of allied sciences who have guided and enabled me to posit their hypotheses
to propagate their pioneering spirit. As Nature's assistant, I do not profess
to cure but merely
to asisst in the healing process. I do not INSIST but merely to suggest by
positing
reserached work of pioneers. What I profess is relevant only to my solo
practice and it does
not reflect the stance of any medical institution. Acceptance of a therapeutic
regime or protocol
is personal. The freedom of choice is best explained and done in an open forum
where there is pooling of researched resources where we learn and share from
one another's mistakes.
< But sometimes there are
hard, cold facts we wish weren't there that require some thinking outside of
the box to get around them. >
Local Nasal Factors Affecting Nasal NO
Alterations in local nasal physiology could affect nasal NO, or
may be mediated by nasal NO.
Nasal volume. Changes in nasal cavity volume could affect
nasal NO by altering NO uptake into nasal blood, and by modulating
the nasal epithelial surface area. Also, the communication
of the nasal cavity with the communicating sinuses, which
produce NO, could be altered. Evidence concerning the influence
of nasal volume on nasal NO is contradictory at present.
Nasal NO output was not volume dependent, provided a true
steady state plateau was achieved, in one study (151) but has
been reported to be volume dependent at low transnasal flow
rates in another (153) possibly owing to changes in nasal aerodynamics
(143).
Nasal aerodynamics. The physics of airflow through the nasal
cavity could alter the sampling of nasal NO. At low flows,
laminar flow may predominate, and certain areas of the cavity
may contribute less NO to the sample. Also at low flows, the
pressure fluxes in the nasal cavity will be less than at high
flows, possibly reducing the efflux of gas from the paranasal sinuses.
Variations in nasal aerodynamics may explain some of
the flow dependency of nasal NO output (143).
Medications and Nasal NO
Medications have been shown to affect NO and should be recorded.
Those reported to have an effect on nasal NO include
nasal decongestants (44, 142), which decrease nasal NO output
by about 15% (151,153). The routine use of decongestants
to facilitate nasal NO measurement itself requires further
study. Nasal steroids have been reported to have no effect in
normal subjects in one study (55), but to reduce nasal NO output
after 2 wk of therapy in normal subjects (78) and asthmatics
(23) in other reports. Antibiotic therapy had no effect on
nasal NO in normal subjects in one study (154) but nasal NO
rose after treatment of sinusitis in another (138). Vasodilators
(e.g., papaverine) increased nasal NO output in one report
(155) whereas histamine had no effect in another study (153).
Saline does not appear to affect nasal NO output (151) but
lidocaine may have a differential effect on nasal and sinus NO
output (140).
Nitric oxide synthase inhibitors. L-NAME administered by
nasal spray has been reported to have no effect in some studies
(47,77,153), but also to decrease NO output (155,156).
L-Arginine. L-Arginine is the substrate for NO synthesis.
Systemic administration increased nasal NO output by 35% in
one study (121) but had no effect when applied by nasal spray
in normal patients (153).
Smoking
A small decrease in nasal NO has been observed in smokers
(145).
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--------- Original Message ---------
DATE: Wed, 18 Jun 2003 10:56:50
From: "C Creel" <[email protected]>
To: <[email protected]>
Cc:
>Dear Lew,
>
>
> I said:
>
><<< I think you need to be talking to the people who are on the frontlines
>of this ...Nebulizing is how they feel a number of health care practitioners
>ended up
>with SARS.>
>
>
>
>You replied:
>
> <<When there is the will and desire, there is always a way. This is
>an open-minded
>forum for health-care. Those in the frontlines battling SARS are welcome
>to share and to
>learn. It is open University with all of us students of Ageless Wisdom.>>
>
>
> ** I think you know I have a great deal of respect for your work. I've
>mentioned this more than once on another list to which we both belong. But
>I think if you are to make a suggestion like NO and insist it CAN be done,
>the onus of responsibility is on you to explain how given what we already
>know about how nebulizing patients with SARS infected those who were
>treating the patients.
>
>
> I've spent a little more than 2 months in daily contact with SARS Task
>Force consisting of people who have tried many different things while
>treating SARS. The testing ground for these things were two hospitals - one
>in Beijing and the other in Hong Kong. Their experiences are valuable.
>When they, who are working every day with patients formally diagnosed as
>having SARS, and you have a hypothesis you've never really gotten to test in
>a formally diagnosed SARS case, it's not difficult for me to decide who has
>the more complete information.
>
>
> I've never been one to accept the status quo, but there is something to
>be said about learning from others' mistakes.
>
>
> Most people who help others heal are very sincere and caring. The
>Universe supports these people as best as it can. But sometimes there are
>hard, cold facts we wish weren't there that require some thinking outside of
>the box to get around them.
>
>
> For example, so many things work in vitro that don't work in vivo. Right
>now, NIH scientists find that licorice is disbling the SARS virus. The
>chances it will do this in vivo are quite slim. But wouldn't it be grand if
>it did?
>
>
> It would be grand if NO worked. In theory it should. It even stands a
>good chance in practice - but only if we can create another delivery system
>that won't risk the lives of others.
>
>
> I'd be glad to introduce your idea to the SARS Task Force if you can come
>up with an idea for a safe way of administering it.
>
>Regards,
>Catherine
>
>
>
>
>
>
>
>
>--
>The silver-list is a moderated forum for discussion of colloidal silver.
>
>Instructions for unsubscribing may be found at: http://silverlist.org
>
>To post, address your message to: [email protected]
>
>Silver-list archive: http://escribe.com/health/thesilverlist/index.html
>
>List maintainer: Mike Devour <[email protected]>
>
>
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