Ode wrote:
So, how many people assume that because something is on the
shelves at the store, it is safe at any dose?
Lots.
One pill for a minor headache...50 pills for a major headache,
right?
They fill emergency rooms year round.
That's very true - acetaminophen, what we call paracetamol in the
UK is a good example. More than 15 grams, or 30 tablets, will
damage most people's livers. Many people feel suicidal, take a
handful of tablets, usually with a lot of booze and go to sleep.
They wake up, feeling more cheerful, collapse with liver failure
a few days later and die slowly and horribly of internal bleeding
over the next week or two, unless they are lucky enough (?!) to
get a liver transplant. The antidotes (either n-acetyl cysteine
or methionine, which will be familiar to many of you) are
effective, but only within 24 hours of the od.
The sickening thing is that this is preventable. If the
pharmaceutical companies put methionine in with the
acetaminophen/paracetamol then overdoses would be relatively
harmless. But the drug would cost more, and it would smell
sulfurous, so people might not buy it, and profits would suffer.
So they let people die horribly instead.
So many people seem to think that if you overdose on anything you
will just go to sleep and never wake up, but this is rarely true.
Aspirin is almost as nasty as acetaminophen - an overdose screws
up your body's acid-base and electrolyte balance and rips out the
lining of your stomach. If you survive the alternating acidosis
and alkalosis, you will likely bleed to death from the holes in
your stomach.
Please spread this around. More people need to know this. I work
in clinical biochemistry, and have spent over 20 years measuring
blood levels of these things for emergency rooms.
And people worry about a remote risk of turning slightly blue!
Paul H
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