Anyone try something simliar to the described protocol? We took all
our RAW files and converted them to OUT files using bioworks seqeust
search. Then using TPP software, we converted all OUTfiles (with a
params file) to pepXML. However, using peptide prophet required doing
it in groupsfor it to work properly, so we decided we'll just make a
few libraries as opposed to one so we can select all of them in
skyline (our final objective).

However, when building a skyline library using command prompt, it
seems to be looking for the mzXML files as well as the pepXML files,
although we never started with mzXML files beceause we just converted
RAW files to pepXML. Would making new mzXML files from the RAW files
fix this problem? Wouldn't all the relevant information be located in
the peptide prophet output pepXML?

Thanks,
Sayeef
Moffitt
proteomics

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