Usually when the search returns no good results (which is what TPP is
telling you here) it is one of three possible options:

1.  Bad data quality
2.  Wrong search parameters (incorrect static mass mod or wrong enzyme
info. etc)
3.  Wrong database (incorrect organism etc)

Please consider these possibilities in your search results.

-David


On Tue, Aug 13, 2013 at 12:00 PM, Rishika Bisaria
<[email protected]>wrote:

> I am sorry but I am really very new to Proteomics and I am not able to
> figure out the reason for error.
>
>
>
>
> On Tue, Aug 13, 2013 at 2:56 PM, David Shteynberg <
> [email protected]> wrote:
>
>> Any reason you would see this other than Tandem search failed to generate
>> results?
>>
>> Parsing search results "SP062512_062912_IP0201_AX01_23to24 (X! Tandem
>> (k-score))"...
>>   => Total of 0 hits.
>>   => Total of 0 decoy hits.
>>   => Total of 0 excluded hits.
>>
>>
>> On Tue, Aug 13, 2013 at 11:41 AM, Rishika Bisaria <
>> [email protected]> wrote:
>>
>>> Hi,
>>> Thank you for the reply.
>>> Actually I want to follow this pipeline:
>>>
>>> Tandem->peptideprophet->q3new->proteinprophet->Q3proteinRatioParser.
>>>
>>> And also when I am using Xinteract , I am getting the below error:
>>>
>>> running: "C:/Inetpub/tpp-bin/ProphetModels.pl -i interact.iproph.pep.xml"
>>> Analyzing interact.iproph.pep.xml ...
>>> Reading NSS model  ...
>>> Reading NRS model  ...
>>> Reading NSE model  ...
>>> Reading NSI model  ...
>>> Reading NSM model  ...
>>> Reading NSP model  ...
>>> Parsing search results "SP062512_062912_IP0201_AX01_23to24 (X! Tandem
>>> (k-score))"...
>>>   => Total of 0 hits.
>>>   => Total of 0 decoy hits.
>>>   => Total of 0 excluded hits.
>>> command completed in 1 sec
>>>
>>> running: "c:/Inetpub/wwwroot/../tpp-bin/PepXMLViewer.cgi -I
>>> c:/xtandem/interact.iproph.pep.xml"
>>>
>>> command "c:/Inetpub/wwwroot/../tpp-bin/PepXMLViewer.cgi -I
>>> c:/xtandem/interact.iproph.pep.xml" failed: Unknown error
>>>
>>> command "c:/Inetpub/wwwroot/../tpp-bin/PepXMLViewer.cgi -I
>>> c:/xtandem/interact.iproph.pep.xml" exited with non-zero exit code:
>>> -1073741819
>>> QUIT - the job is incomplete
>>>
>>>
>>>
>>>
>>>
>>> On Tue, Aug 13, 2013 at 2:28 PM, David Shteynberg <
>>> [email protected]> wrote:
>>>
>>>> You pipeline is missing the InteractParser step.  Once you have a
>>>> pep.xml file from Tandem you can run "xinteract -ip -p0 "on it to generate
>>>> InteractParser->PeptideProphet->iProphet->ProteinProphet pipeline results.
>>>>
>>>> -David
>>>>
>>>>
>>>> On Tue, Aug 13, 2013 at 10:16 AM, Rishika Bisaria <
>>>> [email protected]> wrote:
>>>>
>>>>> Hi,
>>>>> I am able to run successfully the TPP pipeline on one of the mzXML
>>>>> file.But on using TPP on other mzXML file , ProteinProphet is throwing
>>>>> error stating that did you forgot to run PeptideProphet.
>>>>> I have crossed checked all the parameters , they are correct.I am
>>>>> using the latest version of TPP on windows and running it using 
>>>>> commandline.
>>>>>
>>>>> 1.tandem input.xml
>>>>> 2.Tandem2XML output.2013_07_24_13_24_28.t.xml
>>>>> output.2013_07_24_13_24_28.pep.xml
>>>>> 3.PeptideProphetParser output.2013_07_24_13_24_28.pep.xml MINPROB=0.2
>>>>> 4.ProteinProphet output.2013_07_24_13_24_28.pep.xml
>>>>>  c:\Inetpub\wwwroot\out1.prot.xml
>>>>>
>>>>> ****
>>>>>
>>>>> P.S. Everytime I am changing the parameters in input.xml file.I am
>>>>> using k-score function.
>>>>>
>>>>>
>>>>> Thanks,
>>>>> Rishika
>>>>>
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