James, You don't need to go all the length to creating a sqlite proxy RPC as has been suggested. Your service could implement one thing only - a lock to the database file (external to the SQLite locking mechanism, of course). So it only needs to serialize concurrency; the client does the RPC (via either protocol handy to you - http, WCF, whatever) to obtain the lock; then it can safely write to the DB over NFS. As long as all clients pass through the locking mechanism, you are safe.
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