On Sat, 29 Jun 2013 11:37:09 -0700, Paul Brandon wrote:
Or sometimes more generally, 'experimentally naive' meaning not having
previously experienced the experimental conditions, be they drugs or
experimental manupulations.
While I agree with this distinction, I was also thinking of the medical
literature, such as in HIV/AIDS, where people may have been given
certain drugs as treatments for their conditions for purely clinical
reasons --
their doctor recommended/prescribed it. If some of these people try to
enroll in a study for a new drug, the experimenters may recruit people
who have not had experience with a class of drugs (i.e., this would be
an exclusion criterion). The people who are accepted are technically
drug naive even if they might have participated in clinical trials for other
drugs (they are drug naive but not experimentally naive).
-Mike Palij
New York University
[email protected]
On Jun 29, 2013, at 1:10 PM, Mike Palij wrote:
Just to add to Miguel's points below, in drug studies and drug
treatment/intervention studies, one is likely to come across the
phrase "drug naive" meaning that (a) they have not experienced
a drug, like caffeine though today it is hard to know whether
certain drugs like caffeine have never been taken because they
are being included in more products all the time, and (b) a
person with a specific condition, say AIDS or depression,
have not been treated with a particular class of drugs. On
the latter point, SSRIs are the first line of drugs used for
treatment of depression (along with newer drugs like
Norepinephrine Reuptake Inhibitors or NERI and drugs
that have both SSRI and NERI effects) but if these drugs
don't work, a physician might try one of the older tricyclic drugs
like imipramine and say that they are naive to this class of
drugs. Though not a definitive reference, Wikipedia has an
entry on this point; see:
http://en.wikipedia.org/wiki/Drug-na%C3%AFve
It should be clear that, as in the case with animals that have
previously undergone conditioning, previous experience with
drugs even if ineffective, might influence current behavior.
In conditioning studies, previous schedules of reinforcement
might interaction with current schedules while with drugs expectations
(both positive and negative) might affect how a person responds
or interprets their experience of a drug.
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