The only effective difference is that CentOS is that it will always be slightly 
behind RHEL. This is because it is re-compiled from RHEL sources. Those sources 
have to be released before work can start. How long?  It can be significant... 
RHEL 6.0 released Nov 10, 2010.  CentOS 6.0 release July 10, 2011  - 8 months 
to the day.    This may or may not be a problem for you - just something to be 
aware of when your trying to decide.  Personally, I love CentOS and run it on 
many machines. 
Robert F. Porter, MCSE, CCNA, ZCE, OCP-Java
Lead Sr. Programmer / Analyst
Laboratory Information Services
Ochsner Health System
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