Dear Christoph and Sebastian,

Thank you for your suggestions! I will try them out and let you know how it
goes.

Anu


On Fri, Nov 2, 2012 at 6:07 AM, <[email protected]> wrote:

> Hi Anu,
>
> I just have a few things to add:
>
> - after the first iteration, check the density profile after spline
> smoothing in .smooth.dens (compare to the raw density file in .dist.new).
> If there are oscillations, you have to tune the spline parameters.
> - I am not sure postupd scale applies, but you can as well simply reduce
> the prefactor to see if it is to high ( this may very well be if your CG
> model has a different compressibility)
> - Increase the total simulation time per iteration step and trash some of
> the trajectory in the beggining using gromacs.equi_time in the settings file
>
> Good luck!
>
>
> -Sebastian
>
> Zitat von Christoph Junghans <[email protected]>:
>
>  Hi,
>>
>> 2012/10/31 Anu Nagarajan <[email protected]>:
>>
>>> Hi,
>>>
>>> I am trying to run the thermodynamic force using csg_inverse. I have the
>>> settings.xml file with appropriate options for my system. But, when I
>>> try to
>>> run TF, I get about 2-3 iterations after which the temperature gets
>>> really
>>> high and the system becomes unstable. I have the latest version (1.2.3)
>>> of
>>> votca. I computed the prefactor based on the compressibility of the
>>> atomistic region.  According to the tutorial and the paper, I have set
>>> the
>>> TF range to be d(skin)+d(at)+d(hy)+d(skin) where d(skin) is right now
>>> half
>>> the cutoff distance. The entire molecule is one charge group and I have
>>> 12
>>> atoms plus virtual site.  Do I have to change any values in the
>>> settings.xml
>>> file? Is there anything I might be missing?
>>>
>> The parameters will depend on the system you study.
>> Here are some things you could try:
>> - increase adress_ex_forcecap in the mdp file
>> - increase the spline grid (spline_start, spline_end in
>> cg.non-bonded.inverse.tf) in setting.xml
>> - add a cg_prefactor in  cg.non-bonded.inverse.tf, which is based on
>> the compressibility of the cg model
>> - scale the update (add postupd task scale) by something < 1
>>
>> Sebastian, please add stuff if I have missed something.
>>
>> Christoph
>>
>>>
>>> I appreciate any help in this matter!
>>>
>>> Thanks!
>>> Anu
>>>
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>>
>>
>>
>> --
>> Christoph Junghans
>> Web: http://www.compphys.de
>>
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