I'm still baffled by how you get into this state to begin with.  Florent
explained why earlier, and I didn't see a reply to this part:

[Florent Guillaume]
> Huh are you sure? That would mean you have thousands of threads. Or 
> hundreds or ZEO clients. Or hundreds of ZODB mountpoints.
> By itself Zope never uses more than one connection per thread, and the 
> number of thread is usually small.

You replied that you had "hundreds" rather than "thousands" of connections,
but it's a still mystery here how you manage to have that many.  For
example, Zope defaults to using 4 ZServer threads, so do you specify a much
larger zserver-threads value than the default?

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