I've been using nginx with uwsgi: http://projects.unbit.it/uwsgi/ as
documented here:  
http://tonylandis.com/python/deployment-howt-pylons-nginx-and-uwsgi/
I had problems using using 0.9.5.rc1, but, 0.9.4.4 worked fine.

I would not recommend nginx's mod_wsgi as it has problems with
blocking applications: 
http://blog.dscpl.com.au/2009/05/blocking-requests-and-nginx-version-of.html
This is NOT Graham Dumpleton's apache mod_wsgi, it just shares the
name and they appear to have used some of the handler code.

You could also use phusion passenger: http://www.modrails.com/install.html
which queues requests to avoid the blocking experienced with nginx's
mod_wsgi.

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