Are there any all-D proteins out there, of known structure or otherwise? If so, do enantiomer-specific catalyses become inverted?
JPK On Wed, Feb 15, 2012 at 8:05 AM, David Schuller <[email protected]> wrote: > Wukovitz & Yeates (1995) Nature Struc. Biol. 2(12): 1062-1067 > predicts that the most probable space group for macromolecular > crystallization is P -1 (P 1-bar). All you have to do to try it out is > synthesize the all-D enantiomer of your protein and get it to fold properly. > > > On 02/14/12 18:36, Prem Kaushal wrote: > > > Hi > > We have a protein that crystallized in P21212 space group. We are looking > for some different crystal forms. We tried few things did not work. Now we > are thinking to mutate surface residues. Anybody aware of any software which > can predict the mutations that might help in crystallizing protein in > different space group, please inform me. > > Thanks in advance > > Prem > > > -- > > > > -- > ======================================================================= > All Things Serve the Beam > ======================================================================= > David J. Schuller > modern man in a post-modern world > MacCHESS, Cornell University > [email protected] -- ******************************************* Jacob Pearson Keller Northwestern University Medical Scientist Training Program email: [email protected] *******************************************
