Just thinking out loud and following up Tom's post - Could prediction be a guide to sample preparation for detailed binding studies? Andy ________________________________________ De : CCP4 bulletin board [CCP4BB@JISCMAIL.AC.UK] de la part de Luca Pellegrini [lp...@cam.ac.uk] Envoyé : vendredi 4 décembre 2020 10:15 À : CCP4BB@JISCMAIL.AC.UK Objet : Re: [ccp4bb] AlphaFold: more thinking and less pipetting (?)
Exciting times, indeed. I haven’t looked through the results myself, but it does look like an extraordinary advance. I wonder though how this advance correlates with ‘understanding’ how proteins folds. Can these outstanding results be distilled in a set of improved principles for how proteins fold? Ot put it another way, should we invite the AlphaFold programmers to deliver the conclusive lecture on the theory of protein folding? Or maybe we should invite the algorithm to present its results… Best wishes, Luca Luca Pellegrini, PhD Department of Biochemistry University of Cambridge Cambridge CB2 1GA UK On 3 Dec 2020, at 11:17, Isabel Garcia-Saez <isabel.gar...@ibs.fr<mailto:isabel.gar...@ibs.fr>> wrote: Dear all, Just commenting that after the stunning performance of AlphaFold that uses AI from Google maybe some of us we could dedicate ourselves to the noble art of gardening, baking, doing Chinese Calligraphy, enjoying the clouds pass or everything together (just in case I have already prepared my subscription to Netflix). https://www.nature.com/articles/d41586-020-03348-4 Well, I suppose that we still have the structures of complexes (at the moment). I am wondering how the labs will have access to this technology in the future (would it be for free coming from the company DeepMind - Google?). It seems that they have already published some code. Well, exciting times. Cheers, Isabel Isabel Garcia-Saez PhD Institut de Biologie Structurale Viral Infection and Cancer Group (VIC)-Cell Division Team 71, Avenue des Martyrs CS 10090 38044 Grenoble Cedex 9 France Tel.: 00 33 (0) 457 42 86 15 e-mail: isabel.gar...@ibs.fr<mailto:isabel.gar...@ibs.fr> FAX: 00 33 (0) 476 50 18 90 http://www.ibs.fr/ ________________________________ To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 ________________________________ To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
