Hello James, that's really strange - I've used refmac et al., to do poor man's energy minimizations of models and they've generally come out fine, unless the restraints, etc, are wildly off-target. I wasn't playing with X-ray weights though, since there never was a dataset, of course.
Cheers, Jon.C. Sent from ProtonMail mobile -------- Original Message -------- On 4 Dec 2020, 01:34, James Holton wrote: > It is a major leap forward for structure prediction for sure. A hearty > congratulations to all those teams over all those years. > > The part I don't understand is the accuracy. If we understand what holds > molecules together so well, then why is it that when I refine an X-ray > structure and turn the X-ray weight term down to zero ... the molecule blows > up in my face? > > -James Holton > MAD Scientist > > On 12/3/2020 3:17 AM, Isabel Garcia-Saez wrote: > >> Dear all, >> >> Just commenting that after the stunning performance of AlphaFold that uses >> AI from Google maybe some of us we could dedicate ourselves to the noble art >> of gardening, baking, doing Chinese Calligraphy, enjoying the clouds pass or >> everything together (just in case I have already prepared my subscription to >> Netflix). >> >> https://www.nature.com/articles/d41586-020-03348-4 >> >> Well, I suppose that we still have the structures of complexes (at the >> moment). I am wondering how the labs will have access to this technology in >> the future (would it be for free coming from the company DeepMind - >> Google?). It seems that they have already published some code. Well, >> exciting times. >> >> Cheers, >> >> Isabel >> >> Isabel Garcia-SaezPhD >> Institut de Biologie Structurale >> Viral Infection and Cancer Group (VIC)-Cell Division Team >> 71, Avenue des Martyrs >> CS 10090 >> 38044 Grenoble Cedex 9 >> France >> Tel.: 00 33 (0) 457 42 86 15 >> [e-mail: isabel.gar...@ibs.fr](mailto:isabel.gar...@ibs.fr) >> FAX: 00 33 (0) 476 50 18 90 >> http://www.ibs.fr/ >> >> --------------------------------------------------------------- >> >> To unsubscribe from the CCP4BB list, click the following link: >> https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 > > --------------------------------------------------------------- > > To unsubscribe from the CCP4BB list, click the following link: > https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
