A quick note regarding the code that Deepmind released for CASP13 (2018).

It bears the rather important caveat that: "This code can't be used to predict 
structure of an arbitrary protein sequence. It can be used to predict structure 
only on the CASP13 dataset (links below)."

Source: 
https://github.com/deepmind/deepmind-research/tree/master/alphafold_casp13<https://github.com/deepmind/deepmind-research/tree/master/alphafold_casp13>

So whilst we can replicate their previous efforts, we currently can't submit 
our more troublesome sequences to their software, which is (I imagine) 
something that many of us might like to try.

D

--
Dr David C. Briggs
Senior Laboratory Research Scientist
Signalling and Structural Biology Lab
The Francis Crick Institute
London, UK
==
about.me/david_briggs

________________________________
From: CCP4 bulletin board <CCP4BB@JISCMAIL.AC.UK> on behalf of Isabel 
Garcia-Saez <isabel.gar...@ibs.fr>
Sent: Thursday, December 3, 2020, 11:17
To: CCP4BB@JISCMAIL.AC.UK
Subject: [ccp4bb] AlphaFold: more thinking and less pipetting (?)

Dear all,

Just commenting that after the stunning performance of AlphaFold that uses AI 
from Google maybe some of us we could dedicate ourselves to the noble art of 
gardening, baking, doing Chinese Calligraphy, enjoying the clouds pass or 
everything together (just in case I have already prepared my subscription to 
Netflix).

https://www.nature.com/articles/d41586-020-03348-4

Well, I suppose that we still have the structures of complexes (at the moment). 
I am wondering how the labs will have access to this technology in the future 
(would it be for free coming from the company DeepMind - Google?). It seems 
that they have already published some code. Well, exciting times.

Cheers,

Isabel


Isabel Garcia-Saez PhD
Institut de Biologie Structurale
Viral Infection and Cancer Group (VIC)-Cell Division Team
71, Avenue des Martyrs
CS 10090
38044 Grenoble Cedex 9
France
Tel.: 00 33 (0) 457 42 86 15
e-mail: isabel.gar...@ibs.fr<mailto:isabel.gar...@ibs.fr>
FAX: 00 33 (0) 476 50 18 90
http://www.ibs.fr/


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