Yes, I meant maps from SPA. This is the great thing about cryoEM: most maps are 
discovery maps!

I agree that showing crystallographic maps requires more careful explanations 
for non-experts, but I still believe we, as a field trying to make our nerdy 
technical things more approachable to others, are better off showing maps than 
not.

Cheers,

Guillaume


On 17 Mar 2023, at 23:57, Huw Jenkins 
<[email protected]<mailto:[email protected]>> wrote:



On 17 Mar 2023, at 15:01, Guillaume Gaullier 
<[email protected]<mailto:[email protected]>> wrote:

CryoEM papers often show a map in a main figure, and as a reader I think it is 
very nice to show me the map that convinced you of some finding before showing 
me your interpretation of this map.

Surely a key difference is that cryoEM maps (assuming you mean SPA) are not 
calculated with phases derived from the model shown built into the map?

Most maps shown to convince the reader of the validity of the authors 
interpretation of the electron density in X-ray crystallography papers use some 
attempt at removing bias from 2Fo-Fc or Fo-Fc density when the phases have at 
some point in the refinement been derived from a model including the region of 
interest. Few are “discovery maps” to use Dale Tronrud’s term: 
https://www.mail-archive.com/[email protected]/msg04276.html


Huw

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