> -----Original Message-----
> From: Dana [mailto:[EMAIL PROTECTED]
> Sent: Monday, July 18, 2005 5:57 PM
> To: CF-Community
> Subject: the mechanism of action is unknown
> 
> A google of the above phrase turns up references to oral
> anticoagulants, interferon, anti-epileptic medication, mood
> stabilizers, and treatments for breast cancer, parkinson's and
> tuberculosis....
> 
> conclusion - just cause it's not understood doesn't mean it's not
> medecine.

Just because some things that work are not understood doesn't mean that all
things that aren't understood work.  ;^)

I know I'm harping on this but this is the reason for double-blind studies
and control groups.  People who don't know if their getting the real
medicine are dosed by doctors that don't know if they're giving the real
medicine.

It's to link the results to the proper cause: did the drug do what its
supposed to do?  If there's little difference between the test and the
control groups then it seems clear that the drug just isn't doing much.

The actual method of action isn't as important.  Determining that for any
drug can be insanely painstaking as you're hunting down very specific
bio-chemical effects in a vast system.

What frustrates me is the blanket being thrown up: because some things
aren't understood anything is possible.

Comparing a well-tested, well-defined, double-blind proven drug to any of
the ill-tested, loosely-defined therapies out there based simply on the lack
of complete understanding of the former is just unfair.

Jim Davis




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