Did you kill file Dana?

Tim

> -----Original Message-----
> From: Larry C. Lyons [mailto:[EMAIL PROTECTED]
> Sent: Tuesday, July 19, 2005 4:55 PM
> To: CF-Community
> Subject: Re: the mechanism of action is unknown
>
>
> violating kill file here.
>
> google the following (I don't see why I should have to do your
> grunt work here).
>
> real simulator  design
> attentional control/placebo design
> placebo response.
>
> Also get a good text on experimental design in Psychology at the
> graduate level. Pedhauzer et al's Design Measurement and Analysis is a
> good example. These books give quite a few ways of assessing these
> effects.
>
> the idea is to present a valid, but bogus design. The problem is that
> people are gullible and will believe almost anything if presented the
> right way. In addition in research, generally people want to cooperate
> and please the researcher. Therefore they can be very good at
> determining the real objective of the study.
>
> There is not indication of anything you mentioned that does not fit
> within a placebo response paradigm. Unless controlled for, for all
> intents and purposes it esentially fits within a space cadet bs sort
> of belief.
>
>
>
> On 7/19/05, Dana <[EMAIL PROTECTED]> wrote:
> > All very true. But explain to me how you are going to test the
> effect of the
> > mind on healing in a double-blind study? This isn't something from the
> > National Enquirer we're talking about... this is Lancet. Ergo,
> the science
> > is sound, or they would not have published it.
> >  On a slightly different topic there is also a problem with the current
> > paradigm in that drug companies are being relied on for
> research. Based on
> > my adventures in the land of coumadin, I can assure you that a similar
> > effect can be had with either ginko balboa or gingseng.
> However, there is an
> > issue of standardizing the dose, one, and monitoring the very
> considerable
> > side effects. Therefore, people with clotting issues are given
> a substance
> > best known for being a rat poison, rather than a substance best
> known for
> > improving memory, because there is a patent on the former and not the
> > latter.
> >  Dana
> >
> >  On 7/18/05, Jim Davis <[EMAIL PROTECTED]> wrote:
> > >
> > > > -----Original Message-----
> > > > From: Dana [mailto:[EMAIL PROTECTED]
> > > > Sent: Monday, July 18, 2005 5:57 PM
> > > > To: CF-Community
> > > > Subject: the mechanism of action is unknown
> > > >
> > > > A google of the above phrase turns up references to oral
> > > > anticoagulants, interferon, anti-epileptic medication, mood
> > > > stabilizers, and treatments for breast cancer, parkinson's and
> > > > tuberculosis....
> > > >
> > > > conclusion - just cause it's not understood doesn't mean it's not
> > > > medecine.
> > >
> > > Just because some things that work are not understood doesn't
> mean that
> > > all
> > > things that aren't understood work. ;^)
> > >
> > > I know I'm harping on this but this is the reason for
> double-blind studies
> > > and control groups. People who don't know if their getting the real
> > > medicine are dosed by doctors that don't know if they're
> giving the real
> > > medicine.
> > >
> > > It's to link the results to the proper cause: did the drug do what its
> > > supposed to do? If there's little difference between the test and the
> > > control groups then it seems clear that the drug just isn't
> doing much.
> > >
> > > The actual method of action isn't as important. Determining
> that for any
> > > drug can be insanely painstaking as you're hunting down very specific
> > > bio-chemical effects in a vast system.
> > >
> > > What frustrates me is the blanket being thrown up: because some things
> > > aren't understood anything is possible.
> > >
> > > Comparing a well-tested, well-defined, double-blind proven
> drug to any of
> > > the ill-tested, loosely-defined therapies out there based
> simply on the
> > > lack
> > > of complete understanding of the former is just unfair.
> > >
> > > Jim Davis
> > >
> > >
> > >
> > >
> > >
> >
> >
>
> 

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