May 1 will start my wife's 13th year with CML and gleevec.  Her readings are 
normal and she returns to the doctor every 5 weeks.  her problem is she has 
spinal sinuous and has to us a walker.  The CML is in remission. 

 
Don Donofrio




________________________________
From: Frank <[email protected]>
To: CMLHope <[email protected]>
Sent: Tue, March 13, 2012 7:56:24 AM
Subject: [CMLHope] Re: loss of effectiveness of gleevec and sprycel

What were your last 12 months bcr/abl test results? Regards, Frank

On Mar 12, 1:54 pm, skink1100 <[email protected]> wrote:
> I have had cml for nearly 10 years.  For several years I was at the
> not detectable level in my pcr tests.  Last year the gleevec seemed to
> no longer be as effective...and my doctor switched me to
> sprycel...about 4 months ago...my results continue to decline,
> although my blood looks ok.  Has anyone had a similar
> experience...could it be a new mutation?  Where does on go from
> here...getting worried.

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