I was on 600mg per day of gleevec...than 100mg of sprycel...now 140mg 
sprycel

On Monday, March 12, 2012 10:22:49 PM UTC-4, robert goodrich wrote:
>
> just out of curiosity what dosage are you on.....my wife is going on 11 
> years with gleevec,but has always been on a low dosage.....200 mg a 
> day......thank-you rob
>
>    *From:* skink1100 <[email protected]>
> *To:* CMLHope <[email protected]> 
> *Sent:* Monday, March 12, 2012 1:54 PM
> *Subject:* [CMLHope] loss of effectiveness of gleevec and sprycel
>  
> I have had cml for nearly 10 years.  For several years I was at the
> not detectable level in my pcr tests.  Last year the gleevec seemed to
> no longer be as effective...and my doctor switched me to
> sprycel...about 4 months ago...my results continue to decline,
> although my blood looks ok.  Has anyone had a similar
> experience...could it be a new mutation?  Where does on go from
> here...getting worried.
>
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