Mt wife has spinal stenosis and has congestive heart failure with a pace 
maker.  
They won't operate on her because she has two leaky valves an they said she 
could not take the operation. 
Don Donofrio




________________________________
From: Frank <[email protected]>
To: CMLHope <[email protected]>
Sent: Wed, March 14, 2012 6:50:20 AM
Subject: [CMLHope] Re: loss of effectiveness of gleevec and sprycel

I just had very successful Spinal Stenosis surgery at The Mayo Clinic.
I was out in less than 24 Hrs., and am now pain-free! Frank

On Mar 13, 6:42 am, Donald Donofrio <[email protected]>
wrote:
> My wife has been on Gleevec since we went to Detroit in phase three of
> testing. She takes 200 mg. daily.  My name is Don
>
> Don Donofrio
>
> ________________________________
> From: robert goodrich <[email protected]>
> To: "[email protected]" <[email protected]>
> Sent: Mon, March 12, 2012 10:22:49 PM
> Subject: Re: [CMLHope] loss of effectiveness of gleevec and sprycel
>
> just out of curiosity what dosage are you on.....my wife is going on 11 years
> with gleevec,but has always been on a low dosage.....200 mg a 
>day......thank-you
> rob
>
> From: skink1100 <[email protected]>
> To: CMLHope <[email protected]>
> Sent: Monday, March 12, 2012 1:54 PM
> Subject: [CMLHope] loss of effectiveness of gleevec and sprycel
>
> I have had cml for nearly 10 years.  For several years I was at the
> not detectable level in my pcr tests.  Last year the gleevec seemed to
> no longer be as effective...and my doctor switched me to
> sprycel...about 4 months ago...my results continue to decline,
> although my blood looks ok.  Has anyone had a similar
> experience...could it be a new mutation?  Where does on go from
> here...getting worried.
>
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