Hi Bernhard, Many thanks for your reply. Our emails must have literally crossed as I sent an update just now the mailing list. We think it is a CPU issue. By default, when COOT is opened from CCP4i2 it only uses 1 CPU instead of multipe in Windows 11.
FYI - I'm using CCP4-9.0.007 which contains COOT version 0.9.8.95. Hope this helps further, Lisa -----Original Message----- From: Bernhard Lohkamp <bernhard.lohk...@ki.se> Sent: 09 April 2025 12:32 To: Lisa Baker <l.ba...@vernalis.com>; COOT@JISCMAIL.AC.UK Subject: RE: Lag when translating view and cycling through NCS chains Hello Lisa, Sorry to hear you are having issues with the performance/speed of WinCoot on Windows 11. Which WinCoot version are you using? You are not the only one reporting performance issues on Windows 11 (*) although I am not sure if they are all the same and/or related. Until very recently I didn’t have a Windows 11 computer to test myself but I have now... (so far not exposed to any WinCoot building/compilation just testing): I tested WinCoot 0.9.8.95&96 as well as 1.1.14 on Windows 11 and did not find any performance issues (x) Therefore I am unable to do more than give general troubleshooting/testing advise for now: * Antivirus, is it possible for you to (temporarily) disable anti-virus software and/or use another one? I run MS defender and haven’t tried anything else recently * Filesystem, are all files/installation local or on network drives? Having everything local is of course preferred esp the dictionary (which comes from ccp4) and backup * Issue with the pdb file(s). Or is the issue independent of the coordinates used!? Otherwise of course if this is reproducible please send me files (private & confidential of course) and commands so that I can try to reproduce the issue. Cheers, Bernhard (*) these come mainly from industrial users... Maybe industry is forced to migrate to Windows 11 faster than academia 😉 or did WinCoot secretly increase tariffs for certain users 😉 (without me knowing about it) (x) I mainly tested several rounds of automated (animated) refinement which worked all fine without any performance drop. But I did some manual testing esp moving refinement atoms too. *************************************************** Dr. Bernhard Lohkamp | Associate Professor/Lektor/Docent Teaching Unit/Biomedicum D9 Dept. of Medical Biochemistry and Biophysics (MBB) | Karolinska Institutet SE-171 77 Stockholm Sweden +46 8 52487055 bernhard.lohk...@ki.se | ki.se > -----Original Message----- > From: Mailing list for users of COOT Crystallographic Software > <COOT@JISCMAIL.AC.UK> On Behalf Of Lisa Baker > Sent: 08 April 2025 20:46 > To: COOT@JISCMAIL.AC.UK > Subject: Re: Lag when translating view and cycling through NCS chains > > [You don't often get email from l.ba...@vernalis.com. 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