Hi Bernhard, That worked! Thank you so much for your swift help on this issue. COOT is now running as it should and is calling multiple processers by default every time we open it from CCP4i2.
Thank you once again, Lisa -----Original Message----- From: Bernhard Lohkamp <[email protected]> Sent: 09 April 2025 12:43 To: Lisa Baker <[email protected]>; [email protected] Subject: RE: Further update on my issue below - WinCOOT running incredibly slow on Windows11. Hi again, WinCoot should not be restricted to one CPU any more. This was in the past. I am not sure what CCP4 may have done to the startup script though... I located a potential issue in coot.bat, which you find in yourccp4directory/bin. This file has "/affinity 1" in the last line before (coot-bin.exe). Remove this and it should use all available CPUs. If it doesn’t we need to find another place where this may be set and/or the processors are restricted. HTH, B *************************************************** Dr. Bernhard Lohkamp | Associate Professor/Lektor/Docent Teaching Unit/Biomedicum D9 Dept. of Medical Biochemistry and Biophysics (MBB) | Karolinska Institutet SE-171 77 Stockholm Sweden +46 8 52487055 [email protected] | ki.se > -----Original Message----- > From: Mailing list for users of COOT Crystallographic Software > <[email protected]> On Behalf Of Lisa Baker > Sent: 09 April 2025 13:29 > To: [email protected] > Subject: Further update on my issue below - WinCOOT running incredibly > slow on Windows11. > > [You don't often get email from [email protected]. Learn why this > is important at https://aka.ms/LearnAboutSenderIdentification ] > > WinCOOT is defaulting to only using 1 CPU in Windows11. Hence the slow > performance. When you change this in Task Manager to use all > processors then it performs as it should. > > Can a setting be changed within WinCOOT so it defaults to use all > processors as at the moment we're having to do this in Task manager > every time we open WinCOOT. > > Note this problem has affected multiple users on our site, all with > varying PC specs. > > > > > -----Original Message----- > From: Mailing list for users of COOT Crystallographic Software > <[email protected]> On Behalf Of Lisa Baker > Sent: 08 April 2025 19:46 > To: [email protected] > Subject: Re: > > Dear COOT developers/community, > > Has anyone else noticed a drop in performance of ligand > fitting/refinement in WinCoot recently? The drag atom functionality > and refinement is so slow that it is barely useable. > > I don’t know if recent COOT updates or Windows 11 updates are the > cause but any help/diagnosis greatly appreciated. > > Best wishes, > Lisa > > , terms & conditions are available at > https://www/. > jiscmail.ac.uk%2Fpolicyandsecurity%2F&data=05%7C02%7CBernhard.Lohka > mp%40KI.SE%7C73eebf9c480643d6f67308dd7759bcdd%7Cbff7eef1cf4b4f32b > e3da1dda043c05d%7C0%7C0%7C638797950527056064%7CUnknown%7CTW > FpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW > 4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=Q%2Bl > %2FSzyA5s%2FplGpB1pjYanfxBKl07wbn6rjiXYP2JW8%3D&reserved=0 > ________________________________ > > PLEASE READ - This email is confidential and may be privileged. It is > intended for the named addressee(s) only and access to it by anyone > else is unauthorised. 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