OK...Stage...Phase...what ever....
The origional question was about strain....
To me that would be like the Hong Cong Flue...Which we have been
getting a new strain of every year for 50 years +- ...
I have heard that there are a number of strains of FeLV...and I would
think that was the organism that initialy enters the cat.... And the
question was wheather there was a way of identifing the strain....
It is also said that some strains are more likely to turn into B or
C....
Can you share on this thread ???
Tad
Ong Meo wrote:
----- Original Message -----
From: "Tad Burnett" <[EMAIL PROTECTED]>
To: <[EMAIL PROTECTED]>
Sent: Wednesday, December 08, 2004 1:34 PM
Subject: Re: contagiousness of FELV and other thoughts.../strain
I think I have heard of the A, B and C as stages rather than strain...
Subgroups are not the same as stages. There are 6 stages of FeLV infection.
Early Infection (Phases I to 3)
Hemolymphatic and Intestinal
Infection (Phase 4)
Phase 4 is the pivotal phase. If the total virus burden exceeds the cat's
anti-FeLV immune responses, the cat will develop persistent viremia. If the
cat's immune response is successful in limiting or eliminating FeLV, the cat
will develop either latent, extinguished, or sequestered FeLV infection.
Marrow-Origin Viremia (Phase 5)
Widespread Replication of FeLV (Phase 6)
Ong
I have also heard that their are 8 differant strains of the virous...I
would think that would be a part of stage A.....Pretty sure it is
posible to identify what stage the cat is in...but I don't know if there
is anyway to identify what strain an A+ cat has....
FeLV-A is a *subgroup*. All FeLV positive cats are infected with FELV-A.
Subgroups are determined by viral interference assays.
Tad (I don't know what I am talking about but just my guess)
Ong Meo wrote:
----- Original Message -----
From: "Chris" <[EMAIL PROTECTED]>
To: <[EMAIL PROTECTED]>
Sent: Wednesday, December 08, 2004 12:56 PM
Subject: RE: contagiousness of FELV and other thoughts.../strain
Thank you for clarification..
No no. It was my fault for not being clearer. I tend to ramble on since
this disease is always on my mind.
I think I understand now. I guess my question
is do FELV+ cats develop all strains?
Not necessarily.
Or do some get A and then either B or
C?
All FeLV-infected cats are infected with FeLV-A. About 50% of the
FeLV-infected cats generate FeLV-B, and only about 1% generate FeLV-C.
A cat cannot have FeLV-B, or C without having FeLV-A.
Ong.
Chris
[EMAIL PROTECTED]
-----Original Message-----
From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED]] On
Behalf
Of Ong Meo
Sent: Wednesday, December 08, 2004 12:50 PM
To: [EMAIL PROTECTED]
Subject: Re: contagiousness of FELV and other thoughts.../strain
----- Original Message -----
From: "Chris" <[EMAIL PROTECTED]>
To: <[EMAIL PROTECTED]>
Sent: Wednesday, December 08, 2004 12:35 PM
Subject: RE: contagiousness of FELV and other thoughts.../strain
OK-- so what you're saying is that depending on the strain of FELV, it
is
NOT contagious?
No, I don't think that's what I said. I believe I said "FeLV-A occurs
in
all FeLV-infected cats and causes severe immunosuppression" "Only
FeLV-A
is
transmitted contagiously among cats."
"FeLV-B or -C are generated de novo by recombination between endogenous
FeLV
sequences and the infecting FeLV-A. FeLV-B and FeLV-C are not
transmitted
contagiously among cats in nature."
IOW, all FeLV infected cats are infected with FeLV-A which is
tramsmitted
contagiously among cats. FeLV-B and C are generated within the cat by
recombination with the infecting FeLV-A and endogenous FeLV sequences.
I hope this clears up your confusion.
Ong
If so, then it really puts into question the tests
routinely used? What tests could be used to determine the strain?
Chris
[EMAIL PROTECTED]
-----Original Message-----
From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED]] On
Behalf
Of Ong Meo
Sent: Wednesday, December 08, 2004 12:26 PM
To: [EMAIL PROTECTED]
Subject: Re: contagiousness of FELV and other thoughts.../strain
----- Original Message -----
From: "Gloria B. Lane" <[EMAIL PROTECTED]>
To: <[EMAIL PROTECTED]>
Sent: Wednesday, December 08, 2004 9:03 AM
Subject: Re: contagiousness of FELV and other thoughts.../strain
I appreciate the thoughtfulness of what you've written so much. I've
mixed FELV with negatives, no prob. But always a question - shudder.
Have wondered for some time about strains. Does anybody know if
there's an available test for the strain of FELV?
Gloria
Hi Gloria,
I'm new to the group; I hope you don't mind if I butt in.
The differences in the outcome of FeLV infection can be attributed to
differences in virus subgroups that may be considered strains. FeLV-A,
FeLV-B, and FeLV-C.
Only FeLV-A is transmitted contagiously among cats. FeLV-B or -C are
generated de novo by recombination between endogenous FeLV sequences
and
the
infecting FeLV-A. FeLV-B and FeLV-C are not transmitted contagiously
among
cats in nature. The subgroups are determined by viral interference
assays.
These are highly specialized tests and usually available only in
research
and specialized diagnostic labs.
FeLV-A occurs in all FeLV-infected cats and causes severe
immunosuppression
(weakened immune system).
FeLV-B occurs in about 50% of all FeLV-infected cats and causes more
neoplastic disease (i.e., tumors and other abnormal tissue growths)
than
cats infected only with FeLV-A.
FeLV-C occurs in about 1% of FeLV-infected cats and causes severe
anemia.
hth,
Ong
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