Hi all: I scanned this thread just now. I obviously defer to Sue with respect to the genetics. I'm not a big fan of that repeat model being tossed around, BTW, but that's just an opinion. I'm more into developing a multi-allele model-- maybe a more complex eye color model, or the blood ABO +/- Rh model variant-- and plugging in your own numbers using Mendelian inheritance patterns to keep it relatively straight-forward and consistent.
That being said, another diagnosis that utilizes a similar model in terms of repeat sequences is myotonic dystrophy. Its genetics may be better mapped out than either Alzheimer's or Parkinson's, since we've had a chance to study it longer, and the clinical manifestations are readily apparent from an early age, as is the severity, which can then be followed from generation to generation, and frequently directly compared. Also, one mechanism of population control that has yet to be addressed regarding auto-selection--> perhaps the combination of IQ and Magery plays a role in this. Low IQ and high Magery lead to critical failures, ultimately keeping numbers down, and leading to a distribution skew towards higher IQ and high Magery? -vk _______________________________________________ GurpsNet-L mailing list <[email protected]> http://mail.sjgames.com/mailman/listinfo/gurpsnet-l
