Susan Koziel wrote:

On the other hand, I wouldn't go with a mendelian inheritance scheme
at all. I'd probably decide to go with an Alzheimer's type  pattern
in which it seems that multiple copies of a specific portion of a
gene (copies of a motif) lead to an increase in how early in life you
get the disease.

I have a temptation to go for epigenetic effects; inheritable curses and talents are common in magical settings, and various epigenetic switches are a lot more manipulable than conventional Mendelian genetics.
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