A co-worker used frontpanelexpress for a stereo project, and it looked 
stunning. Granted, he paid more for the powder-coat finish and engraved & 
filled lettering. I started a project with their tool, and found it easy to 
use/learn. It has interactive cost-estimation, so you can budget/design 
on-the-fly. As far as an entire case, I believe frontpanelexpress has 
extruded pieces you can select to make a cabinet. It wont be cheap, but it 
will look nice and should be rugged.

All of my nixie clock cases are hand-made, mostly with wood. I probably 
spend as much time making the case as I do designing the PC board. Time is 
money, so that needs to be considered; apparently I dont value my own time 
very much when I spend 50-100 hours making a case. 
---------------------------------
I ended-up doing my own case+front panel using laser-printer decals and 
some 3D-printed pieces (you can see a picture in neonixie by searching for 
nixie bench supply, around Aug 2016. It was a lot of work to make the 
entire case from sheet and angle aluminum. If I had my 3D printer at that 
time, I would have done that instead.

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