Marshall, I think that in the case of accumulation of the particles in the Kupffer cell, accumulation is equivalent to elimination. The Kupffer cell is a specialized macrophage located only in the liver. It's primary purpose is to eliminate old blood cells, particulate materials and microbes from circulation.
See http://biology.about.com/library/organs/bldigestliver2.htm "The liver is host to a very important part of the phagocytic system. Lurking in the sinusoids are large numbers of a type of tissue macrophage known as the Kupffer cell. Kuppfer cells are actively phagocytic and represent the main cellular system for removal of particulate materials and microbes from the circulation. Their location just downstream from the portal vein allows Kupffer cells to efficiently scavenge bacteria that get into portal venous blood through breaks in the intestinal epithelium, thus preventing invasion of the systemic circulation." Now, if you look at the following description on microphages, the second illustration shows how a microphage, such as a Kupffer cell, reaches out and captures a particle or pathogen with it's "arm". The microphage envelops the particle or pathogen and works to break down the ingested material. As shown, the macrophage has a separate path for outputting the waste material. See http://en.wikipedia.org/wiki/Macrophage In the case of the Kupffer cell, the output for the waste passes through the wall of the blood vessel and into an area called the Space of Disse as shown in the following: http://www.drugdevelopment-technology.com/projects/boceprevir/boceprevir 1.html Where it is then passed by the Hepatocyte into the bilary canal. And through the bilary canal into the small intestine. So, I would say that once a particle has entered a Kupffer cell it's only way out is through the feces. - Steve -----Original Message----- From: Marshall Dudley [mailto:[email protected]] Sent: Wednesday, August 26, 2009 7:42 AM To: [email protected] Subject: Re: CS>Silver/Autism/Safety But can accumulation be linked to elimination? For instance can the kidneys eliminate the particles, just not accumulate them, and the liver accumulate but not eliminate them. I am not sure that accumulation is a good indicator of elimination. For instance the spleen is listed as accumulating them, but it would not eliminate them. There simply seems to be a big gap in good research on this. Marshall -- The Silver List is a moderated forum for discussing Colloidal Silver. Instructions for unsubscribing are posted at: http://silverlist.org To post, address your message to: [email protected] Address Off-Topic messages to: [email protected] The Silver List and Off Topic List archives are currently down... List maintainer: Mike Devour <[email protected]>
