Marshall, I planned on reading the article but since I would get a 1 day pass to do so I was planning on waiting for a time when I could spend time searching for other articles too. Plus I know there are other JAMA articles I wanted in the past and I am trying to remember the subjects. If anyone else knows of a JAMA article they want to know about let me know in the next few days if possible. I think you can search at http://jama.ama-assn.org/cgi/reprint/84/13/939.pdf but not read without a subscription.
I know the issue of "what do they mean when they say colloidal silver". I did not use several references because they were not referring to silver particles. Here is one I should have included but I was late for a meeting and in a hurry. It is a generic study for particles and not for any specific particle type. They used gold particles because they are inert and added a silver tracer to the particles. http://www.particleandfibretoxicology.com/content/4/1/10 Kupffer cells are central in the removal of nanoparticles from the organism Some excerpts: "Background The study aims at revealing the fate of nanoparticles administered intravenously and intraperitoneally to adult female mice, some of which were pregnant. Gold nanoparticles were chosen as a model because these particles have been found to be chemically inert and at the same time are easily traced by autometallography (AMG) at both ultrastructural and light microscopic levels. Results Gold nanoparticles were injected intravenously (IV) or intraperitoneally (IP) and traced after 1, 4 or 24 hours. For IV injections 2 and 40 nm particles were used; for IP injections 40 nm particles only. The injected nanoparticles were found in macrophages only, and at moderate exposure primarily in the Kupffer cells in the liver. IV injections resulted in a rapid accumulation/clustering of nanoparticles in these liver macrophages, while the uptake in spleen macrophages was moderate. IP injections were followed by a delayed uptake in the liver and included a moderate uptake in macrophages located in mesenteric lymph nodes, spleen and small intestine. Ultrastructurally, the AMG silver enhanced nanocrystals were found in lysosome-like organelles of the Kupffer cells and other macrophages wherever located. Accumulations of gold nanoparticles were not found in any other organs analysed, i.e. kidneys, brain, lungs, adrenals, ovaries, placenta, and fetal liver, and the control animals were all void of AMG staining. Conclusion Our results suggest that: (1) inert gold nanoparticles do not penetrate cell membranes by non-endocytotic mechanisms, but are rather taken up by endocytosis; (2) gold nanoparticles, independent of size, are taken up primarily by Kupffer cells in the liver and secondarily by macrophages in other places; (3) gold nanoparticles do not seem to penetrate the placenta barrier; (4) the blood-brain barrier seems to protect the central nervous system from gold nanoparticles; (5) 2 nanometer gold particles seem to be removed not only by endocytosis by macrophages, and we hypothesize that part of these tiny nanoparticles are released into the urine as a result of simple filtration in the renal glomeruli." . . . "The finding that both 2 and 40 nm particles accumulate overwhelmingly in the Kupffer cells of the liver is somewhat surprising. Even after IP injections, where a substantial part of the particles must be expected to pass through one or more lymph nodes packed with macrophages, AMG silver enhanced gold particles were found only in relatively few macrophages and only in few animals." . . . "Our findings confirm almost to the point the results of Singer et al. [18] and Adlersberg and Singer [19]. These scientists performed two studies using 300 mice in each study. They exposed mice both IV and IP to both radioactive 198Au and nonradioactive colloidal gold nanoparticles with a diameter of 3-7 nm. Tissues were analyzed by measuring radioactivity and by light microscopy. The dose they used for histological observations was 250 micrograms, i.e. more than 4 times larger than the dose we used. Already one hour after exposure approximately 90% of the nanoparticles were accumulated in the liver while the remaining 10% accumulated in the rest of the body." My supposition that the presence of chloride might affect the way the body excretes the silver chloride molecule is admittedly a SWAG. Pardon my language. But it seemed to fit the data if silver particles pass out through the liver. - Steve -----Original Message----- From: Marshall Dudley [mailto:[email protected]] Sent: Tuesday, August 25, 2009 12:09 PM To: [email protected] Subject: Re: CS>Silver/Autism/Safety Norton, Steve wrote: > Marshall, > As always, I appreciate your comments and correction of my errors. And > my errors are numerous.I did some more searching. There is little > research data on metallic silver that I could find except for inhaled > silver which would probably be converted to silver ions before > assimilation into the bloodstream. The lungs actually secrete H2O2 to break down silver particles in the lungs, which makes silver oxide and silver hydroxide, which is absorbed into the blood stream and most likely quickly converted to silver chloride. > I found a lot of web pages that state > that colloidal silver is removed by the kidneys but could find no > supporting studies. > > I did find the following reference to a JAMA article: > > "Colloidal silver and other similar substances have been proved to be > removed from the blood by the. Kupffer cells in the liver. ... > jama.ama-assn.org/cgi/reprint/84/13/939.pdf" > > Unfortunately this article is for subscribers only. Can you check and make sure they are really talking about colloidal silver? I often find that when one searches deeper in many articles that they are calling many things colloidal silver, including salts and MSP. > And this put out by Stephen Quinto: > > "Stable, pure, and fine silver particles are more likely to be > eliminated first through bile and then secondly through normal kidney > excretion" > http://www.natural-immunogenics.com/pdf/SS-White%20Technical%20Paper%2 > 00 > 02-SafetyInformation-01-23-033.pdf > > > There are a number of studies supporting particle removal by Kupffer > cells in the liver in general but not specific to silver. > The problem is, are any of the references supported by good solid evidence? My theory could certainly be wrong, but with the facts and what I believe to be true seems to fit better than other theories. I wish we could find some really good tests that can pull it all together. There was a debate in 2001 between Stuart and Frank on this very list which concerned this to some extent, where Frank was supporting a chloride hypothesis and Stuart was supporting a ammonia complex hypothesis. That an be found at http://www.gaiaresearch.co.za/silver.html but I cannot say it really adds any light to this. Marshall > Can you point me to something supporting colloidal silver removal by the > kidneys? > > Thanks, > Steve > -- The Silver List is a moderated forum for discussing Colloidal Silver. Instructions for unsubscribing are posted at: http://silverlist.org To post, address your message to: [email protected] Address Off-Topic messages to: [email protected] The Silver List and Off Topic List archives are currently down... List maintainer: Mike Devour <[email protected]>
