Thanks, Dave, and just pointing out that there is a description of  
these options in the usage statement (printed out when running the  
program with no arguments).

Natalie



On Jun 25, 2009, at 9:36 AM, Dave Trudgian wrote:

>
> Matt,
>
> TD filters out data points less than a given intensity, discarding  
> them.
> TZ sets them to zero. You can produce centroid spectra using the
> Accurate Mass Measure function in the tools tab within Masslynx, which
> can batch process raw files.
>
> DT
>
> Matthew Chambers wrote:
>> Hi Bernard,
>>
>> What is TD and TZ? MassLynx doesn't provide centroiding capability so
>> MassWolf has a custom centroiding algorithm. I haven't seen any
>> comprehensive comparisons between that custom algorithm and the  
>> MaxEnt
>> algorithm available from ProteinLynx Global Server (which is not
>> programmatically accessible even if you have access to PLGS!).
>>
>> -Matt
>>
>>
>> Bernt wrote:
>>
>>> Hi Natalie,
>>>
>>> I'm also currently trying out MassWolf 4.2.1......it works with TD  
>>> and
>>> TZ as well, although TD appears to be a better option at generating
>>> smaller mzxml files. But the centroiding function doesn't seem to be
>>> working. It gives a "Warning: using EXPERIMENTAL centroiding
>>> functionality" error msg in command prompt and Windows pops up a
>>> "masswolf.exe has encountered a problem and needs to close" error
>>> report. Is the centroiding function still in the process of
>>> development?
>>>
>>>
>>> Bernard
>>>
>>>
>>> On Jun 25, 5:46 am, Natalie Tasman <[email protected]>
>>> wrote:
>>>
>>>
>>>> Hello,
>>>>
>>>> First, you might want to check that  the file extention is  
>>>> indeed .raw
>>>> and not .RAW.  Capitalization might make a difference.
>>>>
>>>> Can you open this file in the Waters MassLynx application on the  
>>>> same
>>>> computer?  This must be installed in order for the converter
>>>> (massWolf) to work properly.
>>>>
>>>> Natalie
>>>>
>>>> On Jun 24, 2009, at 2:39 PM, Hong wrote:
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>> Hi there,
>>>>>
>>>>> I am new to TPP. I have trouble converting the MassLynx .RAW  
>>>>> directory
>>>>> with mzXML. I got the following status report message. What do I  
>>>>> need
>>>>> to change to get it work? I greatly appreciate your inputs.
>>>>>
>>>>> Hong Li
>>>>> NJ Med School
>>>>>
>>>>> massWolf -v --mzXML c:/Inetpub/wwwroot/ISB/data/hilo08.raw
>>>>>
>>>>> Settings:
>>>>> centroid scans: 0
>>>>> compress scans: 0
>>>>> verbose mode: 1
>>>>> lockspray: 1
>>>>> MS^E: 0
>>>>> threshold: 0
>>>>> mzML mode: 0
>>>>> mzXML mode: 1
>>>>> input filename: c:/Inetpub/wwwroot/ISB/data/hilo08.raw
>>>>> output filename: c:/Inetpub/wwwroot/ISB/data/hilo08.mzXML
>>>>> output file as gzip: 0
>>>>>
>>>>> Command FAILED
>>>>>
>>>>>
>>>
>>>
>>
>>>
>>
>
>
> -- 
> Dr. David Trudgian
> Bioinformatician in Proteomics
> University of Oxford
>
> Tel: (+44) (01865 2)87807       (CCMP - Mon-Thu)
> Tel: (+44) (01865 2)75557       (Dunn Sch - Fri)
>
>
>
>
>
> >


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