The file is Micromass data. It is not odd for the size to read 0K,
this is some sort of artifact of it being a .raw folder. The file is
not corrupt, it opens on MassLynx properly, and can be run through
PLGS with no troubles to a pkl file. It was acquired in MassLynx 4.1
however, might this make a difference as the user is using an older
version?



On Jun 25, 2:36 pm, Natalie Tasman <[email protected]>
wrote:
> Thanks, Dave, and just pointing out that there is a description of  
> these options in the usage statement (printed out when running the  
> program with no arguments).
>
> Natalie
>
> On Jun 25, 2009, at 9:36 AM, Dave Trudgian wrote:
>
>
>
> > Matt,
>
> > TD filters out data points less than a given intensity, discarding  
> > them.
> > TZ sets them to zero. You can producecentroidspectra using the
> > Accurate Mass Measure function in the tools tab within Masslynx, which
> > can batch process raw files.
>
> > DT
>
> > Matthew Chambers wrote:
> >> Hi Bernard,
>
> >> What is TD and TZ? MassLynx doesn't provide centroiding capability so
> >>MassWolfhas a custom centroiding algorithm. I haven't seen any
> >> comprehensive comparisons between that custom algorithm and the  
> >> MaxEnt
> >> algorithm available from ProteinLynx Global Server (which is not
> >> programmatically accessible even if you have access to PLGS!).
>
> >> -Matt
>
> >> Bernt wrote:
>
> >>> Hi Natalie,
>
> >>> I'm also currently trying outMassWolf4.2.1......it works with TD  
> >>> and
> >>> TZ as well, although TD appears to be a better option at generating
> >>> smaller mzxml files. But the centroiding function doesn't seem to be
> >>> working. It gives a "Warning: using EXPERIMENTAL centroiding
> >>> functionality" error msg in command prompt and Windows pops up a
> >>> "masswolf.exe has encountered a problem and needs to close" error
> >>> report. Is the centroiding function still in the process of
> >>> development?
>
> >>> Bernard
>
> >>> On Jun 25, 5:46 am, Natalie Tasman <[email protected]>
> >>> wrote:
>
> >>>> Hello,
>
> >>>> First, you might want to check that  the file extention is  
> >>>> indeed .raw
> >>>> and not .RAW.  Capitalization might make a difference.
>
> >>>> Can you open this file in the Waters MassLynx application on the  
> >>>> same
> >>>> computer?  This must be installed in order for the converter
> >>>> (massWolf) to work properly.
>
> >>>> Natalie
>
> >>>> On Jun 24, 2009, at 2:39 PM, Hong wrote:
>
> >>>>> Hi there,
>
> >>>>> I am new to TPP. I have trouble converting the MassLynx .RAW  
> >>>>> directory
> >>>>> with mzXML. I got the following status report message. What do I  
> >>>>> need
> >>>>> to change to get it work? I greatly appreciate your inputs.
>
> >>>>> Hong Li
> >>>>> NJ Med School
>
> >>>>>massWolf-v --mzXML c:/Inetpub/wwwroot/ISB/data/hilo08.raw
>
> >>>>> Settings:
> >>>>>centroidscans: 0
> >>>>> compress scans: 0
> >>>>> verbose mode: 1
> >>>>> lockspray: 1
> >>>>> MS^E: 0
> >>>>> threshold: 0
> >>>>> mzML mode: 0
> >>>>> mzXML mode: 1
> >>>>> input filename: c:/Inetpub/wwwroot/ISB/data/hilo08.raw
> >>>>> output filename: c:/Inetpub/wwwroot/ISB/data/hilo08.mzXML
> >>>>> output file as gzip: 0
>
> >>>>> Command FAILED
>
> > --
> > Dr. David Trudgian
> > Bioinformatician in Proteomics
> > University of Oxford
>
> > Tel: (+44) (01865 2)87807       (CCMP - Mon-Thu)
> > Tel: (+44) (01865 2)75557       (Dunn Sch - Fri)
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