Hello,
I am not sure if this is the source of the error, but the recommended
procedure to process MASCOT data with the TPP is the following:

1. Convert Thermo .raw file to mzML (or mzXML)  ==> myRun.mzML
2. Convert this file to mgf (using MzXML2Search) ==> myRun.mgf
3. Use this file as an input to MASCOT; MASCOT then generates .dat
file ==> F0123456.dat
4. Rename this to the original base name ==>  myRun.dat
5. Convert to pepXML  ==> myRun.pep.xml
6. Analyze with PeptideProphet, etc.

Let us know if this does not work.  Also, what version of the TPP are you using?

Cheers,
--Luis


On Mon, Jun 27, 2011 at 2:45 PM, Dhruti <[email protected]> wrote:
> I tried to convert Mascot DTA to pepXML using MASCOT2XML program
> without any success. I get following error
>
>    c:/Inetpub/wwwroot/ISB/data/F002856.pep.xml [ Unreadable! ]
>    c:/Inetpub/wwwroot/ISB/data/F002857.pep.xml [ Unreadable! ]
>
> un_in c:/Inetpub/wwwroot/ISB/data; c:\Inetpub\tpp-bin\Mascot2XML c:/
> Inetpub/wwwroot/ISB/data/F002856.dat  -Dc:/Inetpub/wwwroot/ISB/data/
> dbase/uniprot_trembl.fasta -pI -Etrypsin -notgz -desc -shortid
>
> command "c:\Inetpub\tpp-bin\Mascot2XML c:/Inetpub/wwwroot/ISB/data/
> F002856.dat -Dc:/Inetpub/wwwroot/ISB/data/dbase/uniprot_trembl.fasta -
> pI -Etrypsin -notgz -desc -shortid" failed: Unknown error
>
> Command FAILED
>
> THe Dta was generated by searching  thermo  raw files using MASCOT
> 2.3.
>
> THanks
>
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