It ended up being a parameters issue.  Now it's working.  Thanks so much!  

On Monday, July 22, 2013 4:39:50 PM UTC-4, [email protected] wrote:
>
> Kierstin,
>
> You might want to take a 2nd look at what parameters you are also using 
> for X!Tandem.  I find it pretty useful to use the API 
> documentation<http://www.thegpm.org/tandem/api/index.html>as a guide.  What 
> platform are you running TPP on, Windows? and what 
> version of TPP are you using?
>
> -Joe
>
>
>
> On Mon, Jul 22, 2013 at 11:35 AM, Kierstin <[email protected]<javascript:>
> > wrote:
>
>> Thanks Joe!
>>
>> I checked out my spectrum in Pep3D and it looks fine!  For the database 
>> input, I'm using the FASTA file, I'm just using the standard Human 
>> database, and for the parameters, the default tandem parameters file.  I've 
>> gone through it and don't see any special characters.  If you have any 
>> other suggestions, I'll definitely try them!  
>>
>> Thanks,
>>
>> Kierstin
>>
>>
>> On Monday, July 22, 2013 12:23:28 PM UTC-4, [email protected]:
>>
>>> Kierstin,
>>>
>>> Try checking your input to X!Tandem.  Make sure the database doesn't 
>>> have any "bad" sequences in it. Often times special characters sneak into 
>>> the file and can cause X!Tandem to crash.  Also take a look at your 
>>> spectrum -- can you see the input file in Pep3D?
>>>
>>> -Joe
>>>
>>>
>>> On Mon, Jul 22, 2013 at 9:20 AM, Kierstin <[email protected]> wrote:
>>>
>>>> Hi!
>>>>
>>>> Thanks for the suggestion!  I removed all of the spaces and alternate 
>>>> characters and am still getting the same error messages.  Is there 
>>>> anything 
>>>> else I should try?  Should I recheck my parameters file?
>>>>
>>>> Thanks!
>>>>
>>>> Kierstin
>>>>
>>>>
>>>>    - c:/Inetpub/wwwroot/ISB/data/**Tandem/MS13668QE_sample2.**tandem 
>>>> (*file 
>>>>    not found:* not created or deleted?)
>>>>    - 
>>>> c:/Inetpub/wwwroot/ISB/data/**Tandem/MS13668QE_sample2.**tandem.pep.xml 
>>>>    (*file not found:* not created or deleted?) 
>>>>
>>>>  
>>>>
>>>>   Command 1 *[Mon Jul 22 12:11:18 2013] *       [ Show / Hide ] 
>>>>
>>>>  run_in c:/Inetpub/wwwroot/ISB/data/**Tandem; c:\Inetpub\tpp-bin\tandem 
>>>> c:/Inetpub/wwwroot/ISB/data/**Tandem/MS13668QE_sample2.**tandem.params 
>>>>
>>>> ------------------------------
>>>>
>>>> X! TANDEM 2010.10.01.1 (LabKey, Insilicos and ISB)
>>>>
>>>> Loading spectra .
>>>> This application has requested the Runtime to terminate it in an unusual 
>>>> way.
>>>> Please contact the application's support team for more information.
>>>>
>>>> command "c:\Inetpub\tpp-bin\tandem 
>>>> c:/Inetpub/wwwroot/ISB/data/**Tandem/MS13668QE_sample2.**tandem.params" 
>>>> failed: No such process
>>>>
>>>> *Command FAILED* 
>>>>
>>>>
>>>>   Command 2 *[Mon Jul 22 12:11:19 2013] *       [ Show / Hide ] 
>>>>
>>>>  run_in c:/Inetpub/wwwroot/ISB/data/**Tandem; 
>>>> c:\Inetpub\tpp-bin\Tandem2XML 
>>>> c:/Inetpub/wwwroot/ISB/data/**Tandem/MS13668QE_sample2.**tandem 
>>>> c:/Inetpub/wwwroot/ISB/data/**Tandem/MS13668QE_sample2.**tandem.pep.xml 
>>>>
>>>> ------------------------------
>>>>
>>>> Failed to open input file 
>>>> 'c:/Inetpub/wwwroot/ISB/data/**Tandem/MS13668QE_sample2.**tandem'.
>>>>
>>>> command "c:\Inetpub\tpp-bin\Tandem2XML 
>>>> c:/Inetpub/wwwroot/ISB/data/**Tandem/MS13668QE_sample2.**tandem 
>>>> c:/Inetpub/wwwroot/ISB/data/**Tandem/MS13668QE_sample2.**tandem.pep.xml" 
>>>> failed: Operation not permitted
>>>>
>>>> *Command FAILED* 
>>>>
>>>> On Wednesday, July 17, 2013 7:28:22 PM UTC-4, Jimmy Eng wrote:
>>>>
>>>>> Along these lines, everyone should simply avoid any symbols in 
>>>>> directory and file names.  There are some character symbols that are OK 
>>>>> (I 
>>>>> tell folks to use dash '-' and underscore '_' only besides letters and 
>>>>> numbers) but it's best to avoid them all if you don't know which ones 
>>>>> will 
>>>>> work.
>>>>>
>>>>>
>>>>> On Wed, Jul 17, 2013 at 3:28 PM, Brian Hampton <[email protected]>wrote:
>>>>>
>>>>>> Well, I could be wrong, but that space in the directory name is 
>>>>>> probably the culprit.  I would rename the directory .../data/X! Tandem 
>>>>>> to 
>>>>>> something without a space in it.  Just call it .../data/tandem instead.  
>>>>>>
>>>>>> Cheers,
>>>>>>
>>>>>> Brian
>>>>>>
>>>>>> Brian Hampton
>>>>>> Protein Analysis Lab
>>>>>> Center for Vascular and Inflammatory Diseases
>>>>>> University of Maryland School of Medicine
>>>>>> 800 West Baltimore Street Rm 307
>>>>>> Baltimore  MD  21201
>>>>>> V: 410-706-8207
>>>>>> F: 410-706-8234
>>>>>>  
>>>>>>
>>>>>> On Wed, Jul 17, 2013 at 5:24 PM, Kierstin Schmidt <
>>>>>> [email protected]> wrote:
>>>>>>
>>>>>>>  Hi!  
>>>>>>> I am a new user of TPP.  I am trying to load my mzXML files to be 
>>>>>>> searched by X! Tandem, and I keep getting the following errors.  If 
>>>>>>> anyone 
>>>>>>> has advice, it would be greatly appreciated!
>>>>>>>
>>>>>>> Thanks!
>>>>>>>
>>>>>>> Kierstin
>>>>>>>
>>>>>>>
>>>>>>>  "c:/Inetpub/wwwroot/ISB/data/****X! Tandem/MS138QE_sample2.tandem.*
>>>>>>> ***pep.xml (*file not found:* not created or deleted?)
>>>>>>>
>>>>>>> Followed by
>>>>>>>
>>>>>>>  run_in c:/Inetpub/wwwroot/ISB/data/X!****Tandem; 
>>>>>>> c:\Inetpub\tpp-bin\tandem c:/Inetpub/wwwroot/ISB/data/X! 
>>>>>>> Tandem/MS138QE_sample2.tandem.****params 
>>>>>>>
>>>>>>> ------------------------------
>>>>>>>
>>>>>>> X! TANDEM 2010.10.01.1 (LabKey, Insilicos and ISB)
>>>>>>>
>>>>>>> Loading spectra .
>>>>>>> Failed to open: "c:/Inetpub/wwwroot/ISB/data/**X**!Tandem"
>>>>>>> The input parameter file "c:/Inetpub/wwwroot/ISB/data/**X**!Tandem" 
>>>>>>> could not be located.
>>>>>>> Check the file path name and try again.
>>>>>>>
>>>>>>>
>>>>>>> An error was detected while loading the input parameters.
>>>>>>> Please follow the advice above or contact a GPM administrator to help 
>>>>>>> you.
>>>>>>> command "c:\Inetpub\tpp-bin\tandem c:/Inetpub/wwwroot/ISB/data/X! 
>>>>>>> Tandem/MS138QE_sample2.tandem.****params" failed: Unknown error
>>>>>>>
>>>>>>> *Command FAILED* 
>>>>>>>
>>>>>>>
>>>>>>>   Command 2 *[Wed Jul 17 17:11:38 2013] *       [ Show / Hide ] 
>>>>>>>
>>>>>>>  run_in c:/Inetpub/wwwroot/ISB/data/X!****Tandem; 
>>>>>>> c:\Inetpub\tpp-bin\Tandem2XML c:/Inetpub/wwwroot/ISB/data/X! 
>>>>>>> Tandem/MS138QE_sample2.tandem c:/Inetpub/wwwroot/ISB/data/X! 
>>>>>>> Tandem/MS138QE_sample2.tandem.****pep.xml 
>>>>>>>
>>>>>>> ------------------------------
>>>>>>>
>>>>>>>  c:\Inetpub\tpp-bin\Tandem2XML(****TPP v4.5 RAPTURE rev 2, Build 
>>>>>>> 201202031108 (MinGW))
>>>>>>> Usage: c:\Inetpub\tpp-bin\Tandem2XML <input-file> [<output-file>]
>>>>>>>
>>>>>>> command "c:\Inetpub\tpp-bin\Tandem2XML c:/Inetpub/wwwroot/ISB/data/X! 
>>>>>>> Tandem/MS138QE_sample2.tandem c:/Inetpub/wwwroot/ISB/data/X! 
>>>>>>> Tandem/MS138QE_sample2.tandem.****pep.xml" failed: Operation not 
>>>>>>> permitted
>>>>>>>
>>>>>>> *Command FAILED* 
>>>>>>>
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