Here's yet another recent opinion piece on the issue of the 
effectiveness of anti-depressants relative to placebo. Although 
the article doesn't mention it, the discussion fits well with the 
idea referred to in my original post that the problem may be that 
placebos work too well in anti-depressant trials. In the article the 
suggestion is made that mild to moderate depression be first 
treated with placebo.

Of course this is not inconsistent  with Allen Esterson's point 
that depression may not be a unitary entity. Placebos may not 
be useful for severe depression.

See:

Kelly, JH. (March 2, 2010). Antidepressants: Do they "work" or 
don't they? Scientific American 

http://www.scientificamerican.com/article.cfm?id=antidepressant
s-do-they-work-or-dont-they or http://tinyurl.com/ybwoaon

Stephen
--------------------------------------------
Stephen L. Black, Ph.D.          
Professor of Psychology, Emeritus   
Bishop's University               
e-mail:  sblack at ubishops.ca
2600 College St.
Sherbrooke QC  J1M 1Z7
Canada
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