Breeders in England were having this problem 20 years ago.  And they are
still having it.  And we are still having it here.

If we are interested in genetic markers, we could do something about it.
Liz Hansen, Animal Molecular Genetics, University of Missouri, is embarking
on a 5-year study of the canine genome.  They are keeping blood samples for
DNA from families of dogs with apparently hereditary defects.  They started
out with epilepsy (and the info on how to submit samples was at
canine-epilepsy.net, which I can't bring up today), but they are also
studying other genetic conditions.  They want 5-cc blood samples from
affected and unaffected family members.  (They will take 3 cc from a small
dog).  Or, if euthanized, a spleen.  They ask for paperwork, including a
pedigree; all forms downloadable from the site.  Instructions for the blood
sample are also on the site:  EDTA tube, not spun.

Anyone who comes up with an affected litter should consider participating,
for the good of the future of the breed.  I haven't personally had this
condition, so I have not started a DNA study on it, but if anyone is
interested, send the samples to Liz and label the condition "rough coat
syndrome".

I'm not saying ethoxyquin couldn't be a trigger.  But generally there are
genetic predispositions in a condition where one bitch delivers two affected
puppies in different litters.

Leanne

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