On Fri, May 16, 2014 at 07:18:39PM -0700, meekerdb wrote:
> On 5/16/2014 5:17 PM, Russell Standish wrote:
> >On Fri, May 16, 2014 at 11:02:35AM -0700, meekerdb wrote:
> >>On 5/16/2014 12:55 AM, Bruno Marchal wrote:
> >>>>It turns out the carbon atoms in the DNA of neural cells is remarkable
> >>>>long lived, as chronicled via the radiation spike due to atmospheric
> >>>>nuclear weapons testing in 50s & 60s. I don't have a cite on hand,
> >>>>but the result is that your neuronal DNA is on average about two years
> >>>>younger than your own age. For most other cell types, the average age
> >>>>is around 7 years, or something like that.
> >>>That looks like the age of the cell, but all piece of DNA are
> >>>changed many times,
> >>Do you mean replaced by a copy as part of cell metabolism (which I
> >>think happens on cell division?  Or do you mean each DNA molecule
> >>suffers random changes during the life of a cell - due to radiation,
> >>etc.
> >>
> >>>so the age of a DNA does not seem to me to be necessarily the age
> >>>of the atoms making the structure.
> >>Of course the carbon atoms were produce in a super nova and are likely 
> >>millions of years old.
> >>
> >What is being measured is the age of the DNA molecule, not that of the
> >individual atoms. DNA is made up of carbon atoms, and the ratio of
> >Carbon 14 to Carbon 12 will reflect the environmental ratio of those
> >two isotopes at the time the DNA was constructed. In particular,
> >during the period of atmospheric atomic testing, there was a spike in
> >carbon 14, and this is visible in the DNA extracted from neurons of
> >organisms born during that period, indicating that the DNA atoms
> >haven't been replaced during the organism's lifetime.
> 
> Yeah, I understood that.  I wondered about you statement that on
> average a DNA molecule in your neurons was only two years younger
> than your age and a DNA in other parts of your body was only seven
> years younger.  I can understand the first as saying essentially all
> your neurons are in place by age 4.  But to say that say almost all
> your body cells were in place by age 14 and haven't been replaced
> seems like a stretch.  Blood and skin cells certainly have much
> higher turn over rate than that.
> 

Ah, no you misinterpreted me. Perhaps I could have been clearer. The
studies were performed on fresh cadavers, and most body cells were
about 7 years old at time of death. The neurons, on the other hand,
were about two years less than the age of the person at death, which
is to say probably around 70 years old.

-- 

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Prof Russell Standish                  Phone 0425 253119 (mobile)
Principal, High Performance Coders
Visiting Professor of Mathematics      [email protected]
University of New South Wales          http://www.hpcoders.com.au

 Latest project: The Amoeba's Secret 
         (http://www.hpcoders.com.au/AmoebasSecret.html)
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